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Hepatic and renal expression of Oatp1 in obstructive uropathy. First detection of Oatp1 in urine, a potential biomarker
(Wiley Blackwell Publishing, Inc, 2021-07)
Obstructive renal diseases affect renal function and kidney integrity. Nevertheless, little is known about its systemic or extra-renal effects. The organic anion transporting polypeptide 1 (Oatp1) is a carrier expressed ...
Expression of steroid sulfated transporters and 3 beta-HSD activity in endometrium of women having polycystic ovary syndrome
(Elsevier, 2015)
Intracrinology mechanism involves the metabolism of steroids in peripheral tissues, such as DHEA, to molecules with estrogenic or androgenic activity. Proliferation rate of endometria from Polycystic Ovary Syndrome women ...
Influência da exposição ao tolueno por inalação na atividade In Vivo dos transportadores da família Oatp em ratos
(Universidade Estadual Paulista (UNESP), 2016)
Effect of inhalation exposure to toluene on the activity of organic anion transporting polypeptide (Oatp) using pravastatin as a probe drug in rats
(2018-07-03)
1. Toluene, used as a pure substance or in solvent mixtures, is the cause of occupational exposures of large numbers of workers in the world. The organic anion transporting polypeptides (OATP: human; Oatp: rodents) are ...
Effect of inhalation exposure to toluene in Oatp activity using pravastatin as a probe drug in rats
(Elsevier B.V., 2017-10-20)
The conversion of dehydroepiandrosterone into androst-5-ene-3β, 17β-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome
(2010)
The changes in endometrial homeostasis found in women with polycystic ovarian syndrome (PCOS) could be associated with alterations in the intracrine metabolism of steroid hormones. The uptake of dehydroepiandrosterone-sulphate ...
Influência da exposição ao tolueno por inalação na atividade In Vivo dos transportadores da família Oatp em ratos
(Universidade Estadual Paulista (Unesp), 2016-07-20)
A exposição ocupacional a agentes químicos é potencialmente capaz de modificar a disposição cinética ou o metabolismo de fármacos, principalmente em função da indução ou inibição de enzimas do sistema citocromo P450. ...
The conversion of dehydroepiandrosterone into androst-5-ene-3 beta,17 beta-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome
(ELSEVIER, 2010-12)
The changes in endometrial homeostasis found in women with polycystic ovarian syndrome (PCOS)
could be associated with alterations in the intracrine metabolism of steroid hormones. The uptake
of dehydroepiandrosterone-sulphate ...
Impacto do polimorfismo genético do polipeptídeo transportador de ânions orgânicos 1B1 (OATP1B1) na eficácia e segurança da atorvastatina
(Universidade Estadual Paulista (Unesp), 2015-04-24)
A atorvastatina, amplamente utilizada no tratamento de dislipidemias, é fármaco inibidor da enzima 3-hidroxi-3-metilglutaril coenzima A redutase (HMG-CoA) redutase que atua na etapa limitante da síntese do colesterol nas ...