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Whole cell biocatalysts for the preparation of nucleosides and their derivatives
(Bentham Science Publishers, 2017-10)
Nucleosides constitute an extensive group of natural and chemically modified compounds that display a wide range of structures and activities. Different biocatalysts have been developed for their preparation, but the choice ...
An enzymatic alternative for the synthesis of nucleoside 5′-monophosphates
(Elsevier Science Inc, 2018-04)
A new procedure was carried out for the synthesis of nucleoside 5′-monophosphates, involving the use of two enzymes. The first step applied phospholipase D from Streptomyces netropsis and phosphatidylcholine as phosphatidyl ...
Developing a collection of immobilized nucleoside phosphorylases for the preparation of nucleoside analogues: Enzymatic synthesis of arabinosyladenine and 2',3'-dideoxyinosine
(Wiley, 2013-02)
The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides. We purified four recombinantly expressed nucleoside ...
Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
(Pergamon-Elsevier Science Ltd, 2015-06)
Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome ...
Enantiocomplementary Access to Carba-Analogs of C-Nucleoside Derivatives by Recombinant Baeyer-Villiger Monooxygenases
(Elsevier, 2013-03)
A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer–Villiger monooxygenases. Within only three chemo-enzymatic ...
An improved microbial synthesis of purine nucleosides
(Springer, 2000-07)
E. coli BL21 synthesized purine nucleosides from pyrimidine ones. A 94% yield of adenosine from uridine was reached within 1 h.
The salmonella enterica serovar typhi tsx gene, encoding a nucleoside-specific porin, is essential for prototrophic growth in the absence of nucleosides
(AMERICAN SOCIETY FOR MICROBIOLOGY, 2005)