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LncRNA HOTAIR is a novel endothelial mechanosensitive gene
(2020-05-01)
To better address whether the long noncoding RNAs (lncRNAs) HOTAIR and HOTTIP are mechanosensitive genes, they were investigated in differentially challenged endothelial cells with respect to a circuit of tensional forces, ...
Large-scale discovery of previously undetected microRNAs specific to human liver
(Biomed Central Ltd, 2018-03-27)
MicroRNAs (miRNAs) are crucial regulators of gene expression in normal development and cellular homeostasis. While miRNA repositories contain thousands of unique sequences, they primarily contain molecules that are conserved ...
Large-scale discovery of previously undetected microRNAs specific to human liver
(2018-01-26)
MicroRNAs (miRNAs) are crucial regulators of gene expression in normal development and cellular homeostasis. While miRNA repositories contain thousands of unique sequences, they primarily contain molecules that are conserved ...
Computational Detection of MicroRNA Targets
(2022-01-01)
MicroRNAs (miRNAs) are small noncoding RNAs that are recognized as posttranscriptional regulators of gene expression. These molecules have been shown to play important roles in several cellular processes. MiRNAs act on ...
miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data
(2020-07-22)
Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological ...
Competing endogenous RNA networks in the epithelial to mesenchymal transition in diffuse-type of gastric cancer
(MDPI, 2020)
The diffuse-type of gastric cancer is associated with epithelial to mesenchymal transition. Loss of E-cadherin expression is the hallmark of this process and is largely due to the upregulation of the transcription factors ...
Genome-wide hairpins datasets of animals and plants for novel miRNA prediction
(Elsevier, 2019-08)
This article makes available several genome-wide datasets, which can be used for training microRNA (miRNA) classifiers. The hairpin sequences available are from the genomes of: Homo sapiens, Arabidopsis thaliana, Anopheles ...
Novel Risk Associations between microRNA Polymorphisms and Gastric Cancer in a Chilean Population
(2022)
Gastric cancer (GC) is the fifth leading cause of cancer deaths in the world, with variations across geographical regions and ethnicities. Emerging evidence indicates that miRNA expression is dysregulated in GC and its ...
A comparative analysis of heart microRNAs in vertebrates brings novel insights into the evolution of genetic regulatory networks
(2021-12-01)
Background: During vertebrate evolution, the heart has undergone remarkable changes that lead to morphophysiological differences in the fully formed heart of these species, such as chamber septation, heart rate frequency, ...
High Class-Imbalance in pre-miRNA Prediction: A Novel Approach Based on deepSOM
(IEEE Computer Society, 2017-11)
The computational prediction of novel microRNA within a full genome involves identifying sequences having the highest chance of being a miRNA precursor (pre-miRNA). These sequences are usually named candidates to miRNA. ...