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Voltammetric behavior of nitrofurazone and its hydroxymethyl prodrug with potential anti-chagas activity
(2005-07-01)
Chagas' disease is a serious health problem for Latin America. The situation is worsened by the lack of efficient chemotherapy. The two available commercial drugs, benznidazole and nifurtimox, are more effective in the ...
Voltammetric behavior of nitrofurazone and its hydroxymethyl prodrug with potential anti-chagas activity
(2005-07-01)
Chagas' disease is a serious health problem for Latin America. The situation is worsened by the lack of efficient chemotherapy. The two available commercial drugs, benznidazole and nifurtimox, are more effective in the ...
Polarographic determination of nitrofurazone and furazolidone in pharmaceutical formulations and urine
(Royal Society of Chemistry, 1987)
In pyridine - formic acid buffer and tetramethylammonium chloride solution over the pH range 0-8.5, nitrofurazone, furazolidone and other nitrofuran derivatives are reduced in a six-electron process, giving rise to a well ...
Voltammetric behaviour of nitrofurazone, furazolidone and other nitro derivatives of biological importance
(Royal Society of Chemistry, 1987)
In piridine - formic acid buffer and tetramethylammonium chloride solution of pH 4.5 at a dropping mercury or a glassy carbon electrode, nitrofurazone, furazolidone and nitrofurantoin are reduced in a single six-electron ...
Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi
(Taylor & Francis Ltd, 2010-02-01)
Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. NFOH has higher activity and lower mutagenicity. The aim of this work was to assess whether NF and its derivative ...
Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi
(Taylor & Francis Ltd, 2010-02-01)
Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. NFOH has higher activity and lower mutagenicity. The aim of this work was to assess whether NF and its derivative ...
A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds
(Bentham Science Publ Ltd, 2011-11-01)
In therapeutics research, the nitro compounds are part of an important group of drugs with multiple pharmacological activities. However, in drug design, the inclusion of a nitro group in a molecule changes the physico-chemical ...
A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds
(Bentham Science Publ Ltd, 2011-11-01)
In therapeutics research, the nitro compounds are part of an important group of drugs with multiple pharmacological activities. However, in drug design, the inclusion of a nitro group in a molecule changes the physico-chemical ...