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Nanoparticulated Nitric Oxide Donors And Their Biomedical Applications
(Bentham Science Publ LtdSharjah, 2017)
New nitric oxide donors based on ruthenium complexes
(Associação Brasileira de Divulgação Científica, 2009)
Nitric oxide (NO) donors produce NO-related activity when applied to biological systems. Among its diverse functions, NO has been implicated in vascular smooth muscle relaxation. Despite the great importance of NO in ...
Endothelial modulation of a nitric oxide donor complex-induced relaxation in normotensive and spontaneously hypertensive rats
(2018-05-15)
We hypothesized that endothelium modulates relaxation induced by a nitric oxide (NO) donor ruthenium complex (TERPY, [Ru(terpy)(bdq)NO]3+) in mesenteric arteries of normotensive and spontaneously hypertensive (SHR) rats ...
Hypotensive and vasorelaxing effects of the new NO-donor [Ru(terpy)(bdq)NO+](3+) in spontaneously hypertensive rats
(Academic Press Inc. Elsevier B.V., 2012-02-15)
Drugs that release nitric oxide (NO) usually have limitations due to their harmful effects. Sodium nitroprusside (SNP) induces a rapid hypotension that leads to reflex tachycardia, which could be an undesirable effect in ...
Effects on mitochondria of mitochondria-induced nitric oxide release from a ruthenium nitrosyl complex
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
The ruthenium nitrosyl complex trans-[Ru(NO)(NH(3))(4)(py)](PF(6))(3) (pyNO), a nitric oxide (NO) donor, was studied in regard to the release of NO and its impact both on isolated mitochondria and HepG2 cells. In isolated ...
A new NO donor failed to release NO and to induce relaxation in the rat basilar artery
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Nitric oxide (NO)-donors are pharmacologically active substances that in vivo or in vitro release NO. Their most common side effect is headache caused by cerebral vasodilatation. We previously demonstrated that the new ...
Mechanisms underlying the hypotensive and vasodilator effects of Ru(terpy)(bdq)NO](3+), a nitric oxide donor, differ between normotensive and spontaneously hypertensive rats
(Elsevier B.V., 2014-10-15)
The endothelium impairs the vasodilator effect of Ru(terpy)(bdq)NO](3+) (TERPY) in Wistar rat aortas. We hypothesized that endothelial dysfunction could modulate TERPY's effect in spontaneously hypertensive rats. The present ...