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Methylpiperidinium Iodides as novel antagonists for alpha 7 nicotinic acetylcholine receptors
(Frontiers Media, 2018)
The alpha 7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important drug target. We have designed and ...
Methylpiperidinium iodides as novel antagonists for α7 nicotinic acetylcholine receptors
(Frontiers Media S.A., 2018)
© 2018 López, García-Colunga, Pérez and Fierro. The α7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important ...
Novel 2-(substituted benzyl)quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms
(Elsevier, 2013-08)
This work presents the design and synthesis of a series of novel 2-benzylquinuclidine derivatives, comprising 12 methiodide and 11 hydrochloride salts, and their structural and pharmacological characterization at the human ...
Nicotinic antagonist UFR2709 inhibits nicotine reward and decreases anxiety in zebrafish
(MDPI, 2020)
Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery,
mainly due to its ease of handling and low costs involved in maintenance and experimental work.
This animal displays a series of complex ...
Endothelin ETA receptor antagonism attenuates the presser effects of nicotine in rats
(Elsevier Science BvAmsterdamHolanda, 2000)