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The lipid habitats of neurotransmitter receptors in brain
(Elsevier Science, 2016-11)
Neurotransmitter receptors, the macromolecules specialized in decoding the chemical signals encrypted in the chemical signaling mechanism in the nervous system, occur either at the somatic cell surface of chemically excitable ...
In vitro effect of octyl methoxycinnamate (OMC) on the release of Gn-RH and amino acid neurotransmitters by hypothalamus of adult rats
(Thieme Medical Publ Inc, 2010-07)
OMC (octyl-methoxycinnamate), an endocrine disruptor having estrogenic activity, is used in sunscreen creams as UV filter. We studied its in vitro effects on the hypothalamic release of Gn-RH as well as on the amino acid ...
NBAD-hydrolase processing in brain and epidermis of Drosophila melanogaster
(University of Oklahoma, 2011-03)
Drosophila melanogaster genes ebony and tan are responsible for the synthesis and hydrolysis of N-â-alanylderivatives of biogenic amines, such as N-â-alanyldopamine (NBAD) and N-â- alanylhistamine (carcinine). These are ...
Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans
(Nature, 2019-07-18)
Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily conserved. Their primary roles are in cell-to-cell signaling, as biogenic ...
Plasma excitatory amino acids in autism
(Universidad del Zulia, 2013)
Anandamide revisited: How cholesterol and ceramides control receptor-dependent and receptor-independent signal transmission pathways of a lipid neurotransmitter
(MDPI, 2018-06)
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and ...
Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other Membrane-Bound Receptors
(Elsevier Academic Press Inc, 2017-07)
Cholesterol is a ubiquitous neutral lipid, which finely tunes the activity of a wide range of membrane proteins, including neurotransmitter and hormone receptors and ion channels. Given the scarcity of available X-ray ...
Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment
(MDPI, 2021-11)
Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in topographically defined areas. These membrane lateral heterogeneities range ...
RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
(Royal Society Of Chemistry, 2013-04)
We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This photo-trigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photo-cleavage, in a clean and ...