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Neurotoxins as Preclinical Models for Parkinson’s Disease
(Springer New York LLC, 2018)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Translational medicine is one of the major concerns in this century. While significant advances have been made with scientific knowledge, the translation ...
Neurotoxins and neurotoxicity mechanisms. An overview
(Springer New York LLC, 2006)
Neurotoxlns represent unique chemical tools, providing a means to 1) gain insight into cellular mechanisms of apopotosis and necrosis, 2) achieve a morphological template for studies otherwise unattainable, 3) specifically ...
Neurotoxins from Clostridium botulinum (serotype A) isolated from the soil of Mendoza (Argentina) differ from the A-Hall archetype and from that causing infant botulism
(Pergamon-Elsevier Science Ltd, 2016-10)
The type A of neurotoxin produced by Clostridium botulinum is the prevalent serotype in strains of Mendoza. The soil is the main reservoir for C.botulinum and is possibly one of the infection sources in infant botulism. ...
Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from micrurus nigrocinctus nigrocinctus (coral snake) venom
(1996-03)
An ELISA based, non-radioactive acetylcholine receptor (AchR) binding assay was used to detect the alpha-neurotoxins present in Micrurus nigrocinctus nigrocinctus venom. Sera from horses hyperimmunized against M. nigrocinctus ...
Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from micrurus nigrocinctus nigrocinctus (coral snake) venom
(1996-03)
An ELISA based, non-radioactive acetylcholine receptor (AchR) binding assay was used to detect the alpha-neurotoxins present in Micrurus nigrocinctus nigrocinctus venom. Sera from horses hyperimmunized against M. nigrocinctus ...
Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom
(WILEY-BLACKWELLMALDEN, 2012-04)
Scorpion toxins targeting voltage-gated sodium (NaV) channels are peptides that comprise 6076 amino acid residues cross-linked by four disulfide bridges. These toxins can be divided in two groups (a and beta toxins), ...
Human sperm capacitation is necessary for SNARE assembly in neurotoxin‐resistant complexes
(John Wiley and Sons Inc., 2020-03)
Capacitation is not a well‐defined process, required for the acrosome reaction triggered by physiological stimuli. In vitro, capacitation is achieved by sperm incubation in artificial media supplemented with HCO3ˉ, Ca2+, ...
Botulinum neurotoxin: Evolution from poison, to research tool - Onto medicinal therapeutic and future pharmaceutical panacea
(2007)
Botulinum neurotoxin (BoNT), for more than a hundred years, has been a recognized poisonous principle in spoiled food. As its chemical structure became unraveled, and as more knowledge was gained over its mechanism of ...
Crystal Structure of Bucain, a Three-Fingered Toxin from the Venom of the Malayan Krait (Bungarus candidus)
(Bentham Science Publ Ltd, 2009-01-01)
Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 angstrom resolution and based on the molecular ...
Crystal structure of bucain, a three-fingered toxin from the venom of the Malayan krait (Bungarus candidus)
(2009-12-01)
Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 Å resolution and based on the molecular topology ...