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Neurosteroids and neuropathic pain: an up-to-date perspective
(Elsevier, 2022-02)
This perspective aims to broaden our view on the role of neurosteroids, especially progesterone, allopregnanolone, and dehydroepiandrosterone, in the regulation of neuropathic pain. We will make special emphasis on new ...
Progesterone modulates pro-inflammatory cytokine expression profile after spinal cord injury: implications for neuropathic pain
(Elsevier Inc, 2016-03-15)
Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. Glial cell activation and cytokine production contribute to the pathology of central neuropathic syndromes. ...
(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation
(American Chemical Society, 2020-10-19)
The main objective of this study was to determine whether (E)-3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2) and its structural derivative DM489 produce anti-neuropathic pain activity using the streptozotocin (STZ)- and ...
Phenotypes and diagnosis in neuropathic painFenotipos y diagnóstico en dolor neuropático
(Sociedad Española Multidisciplinaria del Dolor, 2021)
Although all the clinical pictures of peripheral neuropathic pain have a common denominator as a characteristic, that is; damage or disease of the somatosensory nervous system, we must estimate that the underlying etiologies ...
(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
(Maney Publishing, 2021-07-19)
Clinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although ...
Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
(Springer/Plenum Publishers, 2018-09-30)
In the last decades, an active and stimulating area of research has been devoted to explore the role of neuroactive steroids in pain modulation. Despite challenges, these studies have clearly contributed to unravel the ...
Potential use of melatonergic drugs in analgesia: Mechanisms of action
(Pergamon-Elsevier Science Ltd, 2010-03)
Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects are mediated by receptors while other, like cytoprotection, seem to depend on direct and indirect scavenging of free radicals not ...
Anti-allodynic and anti-inflammatory effects of 17alpha-hydroxyprogesterone caproate in oxaliplatin-induced peripheral neuropathy
(Wiley Blackwell Publishing, Inc, 2019-01)
Chemotherapy-induced peripheral neuropathy is a disabling condition induced by several frequently used chemotherapeutic drugs including the front-line agent oxaliplatin. Symptoms are predominantly sensory with the development ...
Bone Marrow-Derived Cells and Peripheral Nerve Injury: Translational Implications for Pain and Regeneration Treatments
(All Published, 2018-05)
Traumatic injury of peripheral nerves is a serious concern for both patients and clinicians, and is commonly associated to neuropathicpain and complete or partial loss of functionality of the affected limb. Stem cell therapy ...
Acute modulation of calcium currents and synaptic transmission by gabapentinoids
(Landes Bioscience, 2010-12)
Gabapentin and pregabalin are anticonvulsant drugs that are extensively used for the treatment of several neurological and psychiatric disorders. Gabapentinoids (GBPs) are known to have a high affinity binding to α2 δ-1 ...