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RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
(2018-02-01)
Chronic inflammatory reactions are consistenly present in neurodegeneration of Alzheimer type and are considered important factors that accelerate progression of the disease. Receptors of innate immunity participate in ...
Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons duringparkinson's disease
(2013-05-15)
Emerging evidence has demonstrated that CD4+ T cells infiltrate into the substantia nigra (SN) in Parkinson's disease (PD) patients and in animal models of PD. SN-infiltrated CD4+ T cells bearing inflammatory phenotypes ...