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Potentiation of local anesthetic activity of neosaxitoxin with bupivacaine or epinephrine: Development of a long-acting pain blocker
(2009)
Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, ...
Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model
(Pergamon-Elsevier Science LTD, 2018)
Local anesthesia is an effective method to control pain. Neosaxitoxin is a phycotoxin whose molecular mechanism includes a reversible inhibition of voltage gated sodium channels at the axonal level, impeding nerve impulse ...
First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome
(Springer, 2015)
Introduction and hypothesis Neosaxitoxin is a phycotoxin
whose molecular mechanism of action shows a reversible
inhibition of voltage-gated sodium channels at the axonal level,
impeding nerve impulse propagation. This ...
In vivo blockade of ovarian sympathetic activity by neosaxitoxin prevents polycystic ovary in rats
(Biocientífica, 2020)
A high sympathetic tone is observed in the development and maintenance of the polycystic ovary (PCO)
phenotype in rats. Neosaxitoxin (NeoSTX) specifically blocks neuronal voltage-dependent Na+
channels, and we studied ...
Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin
(Elsevier B.V., 2018)
© 2018 Elsevier B.V. Background: Neosaxitoxin (NeoSTX) and related paralytics shellfish toxins has been successfully used as local anesthetic and muscle relaxants to treat a variety of ailments. The primary mechanism of ...
Neosaxitoxin, a Long-Lasting Local Anesthetic and its Potential Clinical Applications in Horses
(Faculty of Veterinary Sciences - Universidad Austral de Chile, 2023)