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Ion permeation in normal and batrachotoxin-modified Na+ channels in the squid giant axon
(1991)
Na+ permeation through normal and batrachotoxin (BTX)-modified squid axon Na+ channels was characterized. Unmodified and toxin-modified Na+ channels were studied simultaneously in outside-out membrane patches using the ...
Voltage-Gated K+/Na(+)Channels and Scorpion Venom Toxins in Cancer
(Frontiers Media, 2020)
Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, ...
Hyperkalemic periodic paralysis M1592V mutation modifies activation in human skeletal muscle Na+ channel
(1999)
Mutations in the human skeletal muscle Na+ channel underlie the autosomal dominant disease hyperkalemic periodic paralysis (HPP). Muscle fibers from affected individuals exhibit sustained Na+ currents thought to depolarize ...
Actin modifies Ca2+ block of epithelial Na+ channels in planar lipid bilayers
(BIOPHYSICAL SOCIETY, 2001-05)
The mechanism by which the cytoskeletal protein actin affects the conductance of amiloride-sensitive epithelial sodium channels (ENaC) was studied in planar lipid bilayers. In the presence of monomeric actin, we found a ...
Functional transplantation of chloride channels from the human syncytiotrophoblast microvillous membrane to Xenopus oocytes
(2002)
The materno-fetal transfer of metabolites and nutrients requires the operation of specific transport mechanisms through syncytiotrophoblast membranes. Electrophysiological studies on these cells are scarce and, because of ...
Cilium-attached and excised patch-clamp recordings of odourant-activated Ca-dependent K channels from chemosensory cilia of olfactory receptor neurons
(2004)
It has previously been proposed that a Ca2+-dependent K + conductance is implicated in the inhibitory odourant response in rat and toad olfactory receptor neurons. Previous whole-cell and single-channel measurements on ...
Clustering and coupled gating modulate the activity in KcsA, a potassium channel model
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-07-07)
Different patterns of channel activity have been detected by patch clamping excised membrane patches from reconstituted giant liposomes containing purified KcsA, a potassium channel from prokaryotes. The more frequent ...
Mouse sperm patch-clamp recordings reveal single Cl- channels sensitive to niflumic acid, a blocker of the sperm acrosome reaction
(1998)
Ion channels lie at the heart of gamete signaling. Understanding their regulation will improve our knowledge of sperm physiology, and may lead to novel contraceptive strategies. Sperm are tiny (~ 3 μm diameter) and, until ...
Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus
(2002)
The ability of neurons to fire rapid action potential relies on the expression of voltage-gated sodium channels; the onset of the transcription of genes that encode these channels occurs during early neuronal development. ...