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Aminoglycoside modifying enzymes
(Churchill Livingstone, 2010-09)
Aminoglycosides have been an essential component of the armamentarium in the treatment of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and dissemination of resistance. In some ...
On the ancestral UDP-glucose pyrophosphorylase activity of GalF from Escherichia coli
(Frontiers Research Foundation, 2015-11)
In bacteria, UDP-glucose is a central intermediate in carbohydrate metabolism. The enzyme responsible for its synthesis is encoded by the galU gene and its deletion generates cells unable to ferment galactose. In some ...
Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics
(BIOMED CENTRAL LTDLONDON, 2013-08-02)
Background: Proteinaceous toxins are observed across all levels of inter-organismal and intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin systems implicated in intra-specific conflicts. ...