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Nitric oxide synthase inhibitors improve prepulse inhibition responses of Wistar rats
(ELSEVIER SCIENCE BV, 2011)
Introduction: Cognitive and attentional deficits in schizophrenia include impairment of the sensorimotor filter as measured by prepulse inhibition (PPI). In this way, the study of animals that naturally present low PPI ...
Effects of inducible nitric oxide synthase inhibition in bronchial vascular remodeling-induced by chronic allergic pulmonary inflammation
(INFORMA HEALTHCARE, 2011)
Vascular remodeling is an important feature in asthma pathophysiology. Although investigations suggested that nitric oxide (NO) is involved in lung remodeling, little evidence established the role of inducible NO synthase ...
Protective effects of BAY 41-2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAME treatment in rats
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2006)
Inhibitory pathways and the inhibition of luteinizing hormone-releasing hormone release by alcohol
(National Academy of Sciences, 2000-02)
In this research we examined the mechanisms by which ethanol (EtOH) inhibits luteinizing hormone-releasing hormone (LHRH) release from incubated medial basal hypothalamic explants. EtOH (100 mM) stimulated the release of ...
Ativação da nNOS pela via PKA/PP1: implicações na captação de LDL oxidada via Toll Like Receptor 4
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2018-03-27)
nNOS has been described as atheroprotective and its activity is compromised in hyperlipidemia.
However, there is no known relationship of receptors recognizing modified LDL in macrophages and
nNOS activity. in this work ...
Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages
(2002)
Inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production was demonstrated in J774-G8 macrophages infected with Leishmania (L.) amazonensis promastigotes. The downmodulation of NO production observed in ...
Cognitive interference as a possible therapeutic strategy to prevent expression of benzodiazepine withdrawal
(Wiley Blackwell Publishing, Inc, 2019-07-12)
Benzodiazepines are usually prescribed for anxiety and sleep disorders in long-term schedules that may cause drug dependence. Discontinuation after prolonged administration may lead to withdrawal expression, being anxiety ...
Inhibition of nitric oxide is a good therapeutic target for bladder tumors that express iNOS
(Elsevier, 2014-01)
Bladder cancer is the second cause of death for urological tumors in man. When the tumor is nonmuscle invasive, transurethral resection is curative. On the other hand, radical cystectomy is the treatment chosen for patients ...
Inhibition of iNOS induces antidepressant-like effects in mice: Pharmacological and genetic evidence
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Recent evidence has suggested that systemic administration of non-selective NOS inhibitors induces antidepressant-like effects in animal models. However, the precise involvement of the different NOS isoforms (neuronal-nNOS ...
Melatonin inhibits LPS-induced NO production in rat endothelial cells
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Endothelial cells produce NO by activation of constitutive nitric oxide synthase (NOS) and transcription of inducible NOS (iNOS). We have previously shown that melatonin, in the nanomolar range, inhibits activation of ...