A brain endogenous factor, termed endobain E, allosterically decreases [ 3H]dizocilpine binding to NMDA receptor. Such effect depends on receptor activation by the coagonists glutamate and glycine and is interfered by ...

Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson´s disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal ...

It is known that a consolidated memory can return to a labile state and become transiently malleable following reactivation. This instability is followed by a restabilization phase termed reconsolidation. In this work, we ...

Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided ...

Memantine is reported to improve symptoms in moderate cases of Alzheimer´s disease and Parkinson´s disease, but is also known to trigger psychosis in some Parkinson patients. Because these clinical features suggested a ...

The present report further analyzes the survival promoting effect of high potassium, a condition that mimics neural activity in cultured cerebellar granule cells, an excellent model to study trophic mechanisms induced by ...

Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) ...