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The Effect of Endogenous Modulator Endobain E on NMDA Receptor Is Interfered by Zn 2+ but Is Independent of Modulation by Spermidine
(Springer/Plenum Publishers, 2004-04)
A brain endogenous factor, termed endobain E, allosterically decreases [ 3H]dizocilpine binding to NMDA receptor. Such effect depends on receptor activation by the coagonists glutamate and glycine and is interfered by ...
Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
(Elsevier Inc, 2012-03)
Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson´s disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal ...
An appetitive experience after fear memory destabilization attenuates fear retention: Involvement GluN2B-NMDA receptors in the basolateral amygdala complex
(Cold Spring Harbor Laboratory Press, 2016-09)
It is known that a consolidated memory can return to a labile state and become transiently malleable following reactivation. This instability is followed by a restabilization phase termed reconsolidation. In this work, we ...
Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
(Pergamon-Elsevier Science Ltd, 2002-06)
Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided ...
Memantine agonist action at dopamine D2High receptors
(Veterinary and Human Toxicology, 2008-02)
Memantine is reported to improve symptoms in moderate cases of Alzheimer´s disease and Parkinson´s disease, but is also known to trigger psychosis in some Parkinson patients. Because these clinical features suggested a ...
NMDA receptors contribute to the survival promoting effect of high potassium in cultured cerebellar granule cells
(Pergamon-Elsevier Science Ltd, 2005-10)
The present report further analyzes the survival promoting effect of high potassium, a condition that mimics neural activity in cultured cerebellar granule cells, an excellent model to study trophic mechanisms induced by ...
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
(Academic Press Inc Elsevier Science, 2018-11)
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) ...
Interneuron NMDA receptor ablation induces hippocampus-prefrontal cortex functional hypoconnectivity after adolescence in a mouse model of schizophrenia
(Society for Neuroscience, 2020-04)
Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia’s ...
NMDA and group I metabotropic glutamate receptors activation modulates substance P release from the arcuate nucleus and median eminence
(Elsevier Ireland, 2006-01)
Glutamate participates in the regulation of secretion of several neuropeptides, including substance P (SP). Glutamate acts through ionotropic (iGluRS) and metabotropic (mGluRS) receptors. We have investigated whether ...
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
(Nature Publishing Group, 2009-11)
Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was ...