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New insights about the posttranscriptional mechanisms triggered by iodide excess on sodium/iodide symporter (NIS) expression in PCCl3 cells
(ELSEVIER IRELAND LTDCLARE, 2012)
Iodide excess acutely downregulates NIS mRNA expression, as already demonstrated. PCCl3 cells treated or not with Nal, Nal + NaClO4 or Nal + Methimazole, for 30 min to 24 h, were used to further explore how iodide reduces ...
The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane
(Federation of American Societies for Experimental Biology, 2021-07)
The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis. Loss-of-function NIS variants cause ...
Asn441 plays a key role in folding and function of the Na+/I− symporter (NIS)
(Federation of American Societies for Experimental Biology, 2013-05)
The Na+/I− symporter (NIS) is a plasma membrane glycoprotein that mediates active I− transport in the thyroid, the first step in the biosynthesis of the iodine-containing thyroid hormones T3 and T4. Several NIS mutants ...
Iodide Transport Defect: Functional Characterization of a Novel Mutation in the Na(+)/I(-) Symporter 5 `-Untranslated Region in a Patient with Congenital Hypothyroidism
(ENDOCRINE SOC, 2011)
Context: Iodide transport defect (ITD) is an autosomal recessive disorder caused by impaired Na(+)/I(-) symporter (NIS)-mediated active iodide accumulation into thyroid follicular cells. Clinical manifestations comprise a ...
Seven-year follow-up of a juvenile female with papillary thyroid carcinoma with poor outcome, BRAF mutation and loss of expression of iodine-metabolizing genes
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-11-01)
BACKGROUND: Recent studies reported that BRAF V600E mutation, the most prevalent genetic event found in papillary thyroid carcinoma, is an independent poor prognostic marker. Additionally, it correlates with a less ...
Na+/ I- symporter (NIS) expression and localization during rapid transport inhibition by iodide excess.
(2010)
Preferred Presentation Method: Poster Presentation
Abstract: Iodide (I-) uptake is the first and limiting step of thyroid hormone synthesis and is mediated by Na+/I- symporter
(NIS). The expression and function of NISis ...
Low expression of sodium iodide symporter identifies aggressive thyroid tumors
(Elsevier B.V., 2003-10-08)
A decreased radioiodine uptake is frequently detected in differentiated thyroid carcinomas (DTC) and is associated with high recurrence rate and reduced survival. We investigated the correlation between NIS mRNA expression ...
ENTRE FAZENDA FORTALEZA DE SANT???ANNA E ASSENTAMENTO D??NIS GON??ALVES Projeto de Interven????o no Conjunto Edificado da Sede
(Faculdade de Arquitetura e UrbanismoMestrado Profissional em Conserva????o e Restaura????o de Monumentos e N??cleos Hist??ricos da Universidade Federal da Bahia (MP-CECRE UFBA)UFBAbrasil, 2019-03-13)
Association of low sodium-iodide symporter messenger ribonucleic acid expression in malignant thyroid nodules with increased intracellular protein staining
(ENDOCRINE SOC, 2008)
Context: The expression of sodium iodide symporter (NIS) is required for iodide uptake in thyroid cells. Benign and malignant thyroid tumors have low iodide uptake. However, previous studies by RT-PCR or immunohistochemistry ...