Now showing items 1-10 of 610
Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2012)
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic ...
Sudden bilateral deafness from hyperleukocytosis in chronic myeloid leukemia
Sudden-onset bilateral deafness as a clinical manifestation of hyperleukocytosis in chronic myeloid leukemia (CML) is a rare occurrence. We found only 27 clinical descriptions in 16 published papers. In this work, the ...
Acute leukemias in Piaui: comparison with features observed in other regions of Brazil
(Assoc Bras Divulg CientificaSao PauloBrasil, 2003)
Targeting the Acute Myeloid Leukemia Stem Cells
(BENTHAM SCIENCE PUBL LTD, 2010)
The idea that within the bulk of leukemic cells there are immature progenitors which are intrinsically resistant to chemotherapy and able to repopulate the tumor after treatment is not recent. Nevertheless, the term leukemia ...
Characterization of episodes of febrile neutropenia in children with acute myeloid leukemia and acute lymphoblastic leukemia Caracterización de los episodios de neutropenia febril en niños con leucemia mieloide aguda y leucemia linfoblástica aguda
(Sociedad Chilena de Infectologia, 2014)
Introduction: Leukemia is the most common cancer in Chilean children. Acute lymphoblastic leukemia (ALL) is more prevalent and longer survival compared to acute myeloid leukemia (AML). Aims: To describe episodes of febrile ...
RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM)
(Elsevier Inc, 2017-04)
In this review, we discuss disease-causing alterations of RUNT-related transcription factor 1 (RUNX1), a master regulator of hematopoietic differentiation. Familial platelet disorder with predisposition to myeloid leukemia ...
Atypical chromosome abnormalities in acute myeloid leukemia type M4
(Sociedade Brasileira de Genética, 2007-01-01)
This study reports an adult AML-M4 patient with atypical chromosomal aberrations present in all dividing bone marrow cell at diagnosis: t(1;8)(p32.1;q24.2), der(9)t(9;10)(q22;?), and ins(19;9)(p13.3;q22q34) that may have ...