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Multiple ribosomal RNA operons in bacteria; their concerted evolution and potential consequences on the rate of evolution of their 16S rRNA
(Frontiers Media, 2018-06)
Bacterial species differ greatly in the number and location of the rRNA operons which may be present in the bacterial chromosomes and plasmids. Most bacterial species contain more than one ribosomal RNA operon copy in their ...
Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod
(Dove Press Limited, 2016)
Both proprietary and nonproprietary medicines are expected to undergo rigorous preapproval testing and both should meet stringent health authority regulatory requirements related to quality to obtain approval. Nonproprietary ...
Clinical implications for substandard, nonproprietary medicines in multiple sclerosis: focus on fingolimod
(Dove Press Limited, 2016)
Both proprietary and nonproprietary medicines are expected to undergo rigorous preapproval testing and both should meet stringent health authority regulatory requirements related to quality to obtain approval. Nonproprietary ...
Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas
(Nature, 2010)
BACKGROUND: Lung squamous cell carcinomas (SqCCs) occur at higher rates following arsenic exposure. Somatic DNA copy-number
alterations (CNAs) are understood to be critical drivers in several tumour types. We have assembled ...
Quantitative analysis of CKS1B mRNA expression and copy number gain in patients with plasma cell disorders
(Academic Press Inc Elsevier Science, 2014-09)
In this study, we have examined CKS1B gene expression and copy number in a total of 114- patients at diagnosis: 83 with multiple myeloma (MM) and 31 with monoclonal gammopathy of undetermined significance (MGUS). Results ...
Challenges in Clinico-Genetic Correlations in Parkinson’s disease (PD): The Role of Copy Number Variants (CNV)
(SciVision Publishers, 2021-08)
Parkinson’s disease (PD) represents the second most common neurodegenerative disease and remains incurable. Mutations in multiple genes have been linked to monogenic PD (gPD); these monogenic forms, however, represent a ...
Multistate voter model with imperfect copying
(American Physical Society, 2019-10)
The voter model with multiple states has found applications in areas as diverse as population genetics, opinion formation, species competition, and language dynamics, among others. In a single step of the dynamics, an ...
Characterization of the acetohydroxyacid synthase multigene family in the tetraploide plant Chenopodium quinoa
(PUCV, 2015)
Background: Currently, the technology called Clearfield (R) is used in the development of crops resistant to herbicides that inhibit the enzyme acetohydroxy acid synthase (AHAS, EC 2.2.1.6). AHAS is the first enzyme of the ...