Buscar
Mostrando ítems 1-10 de 157
Role of the unfolded protein response in organ physiology: lessons from mouse models
(2013)
The endoplasmic reticulum (ER) is a key subcellular compartment involved in the folding and maturation of around one-third of the total proteome. Accumulation of misfolded proteins in the ER lumen engages a signal transduction ...
Development of an orthotopic model of human metastatic prostate cancer in the NOD‑SCIDγ mouse (Mus musculus) anterior prostate
(2015)
Prostate cancer is one of the most prevalent oncological diseases in males worldwide, and the mortalities resulting from this type of cancer are mainly due to metastasis. The most common models for the study of metastasis ...
Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome)
(1994)
The trisomy-16 (TS16) mouse is considered to be a model of human trisomy 21 (Down syndrome) because of genetic homology between mouse chromosome 16 and human chromosome 21. We examined cholinergic function of brain and ...
Multiple behavior phenotypes of the fragile - X syndrome mouse model respond to chronic inhibition of phosphodiesterase - 4D (PDE4D)
(Nature Publishing Group, 2017)
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent ...
The robertsonian phenomenon in the house mouse: mutation, meiosis and speciation
(Springer Science and Business Media Deutschland GmbH, 2014)
© 2014, Springer-Verlag Berlin Heidelberg. Many different chromosomal races with reduced chromosome number due to the presence of Robertsonian fusion metacentrics have been described in western Europe and northern Africa, ...
Altered calcium currents in cultured sensory neurons of normal and trisomy 16 mouse fetuses, an animal model for human trisomy 21 (Down Syndrome)
(SOCIEDAD BIOLGIA CHILE, 2006)
Down syndrome is determined by the presence of an extra copy of autosome 21 and is expressed by multiple abnormalities, with mental retardation being the most striking feature. The condition results in altered electrical ...
Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells
(NATL ACAD SCIENCES, 2012-12-04)
Despite a high degree of conservation, subtle but important differences exist between the CD1d antigen presentation pathways of humans and mice. These differences may account for the minimal success of natural killer T ...
Parity dependent hemosiderin and lipofuscin accumulation in the reproductively aged mouse ovary
(Hindawi, 2018)
The progressive decline of the ovarian follicle pool leads to reproductive ageing. The latter is accompanied by age-related disorders, including various types of cancer. In fact, the highest rates of ovarian cancer (OC) ...
A novel in vivo model to study impaired tissue regeneration mediated by cigarette smoke
(Nature Publishing Group, 2018)
Cigarette smoke is associated with several pathologies including chronic respiratory diseases and cancer. In addition, exposure to cigarette smoke is correlated with impaired wound healing, where a significant decrease in ...