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Abscisic acid’s role in the modulation of compounds that contribute to wine quality
(Molecular Diversity Preservation International, 2021-05)
Abscisic acid (ABA) plays a crucial role in the plant responses to environmental signals, in particular by triggering secondary metabolism. High-altitude vineyards in Mendoza, Argentina, are exposed to elevated solar ...
Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds
(American Chemical Society, 2018-08)
The Polo-like kinases (Plks) are an evolutionary conserved family of Ser/Thr protein kinases that possess, in addition to the classical kinase domain at the N-terminus, a C-terminal polo-box domain (PBD) that binds to ...
Insights of Gut Microbiota: Probiotics and Bioactive Compounds
(Frontiers Media, 2021-11)
The human body harbors a multitude of microorganisms, including bacteria, fungi, archaea, and viruses, which exist in a symbiotic relationship with their host. The entirety of these commensals is referred to as the microbiota, ...
Fast two-photon neuronal imaging and control using a spatial light modulator and ruthenium compounds
(SPIE - the international society for optics and photonics, 2010-03)
We have developed a spatial light modulator (SLM) based microscope that uses diffraction to shape the incoming two-photon laser source to any arbitrary light pattern. This allows the simultaneous imaging or photostimulation ...
Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
(Lawrence Erlbaum Assoc Inc-taylor & Francis, 2018-02-21)
Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune ...
Allosteric modulation of α7 nicotinic receptors by flavonoids
(SAGE Publications, 2018)
Plants have emerged as a valuable source for neuroprotective compounds like flavonoids. These polyphenolic com pounds decrease neurotoxicity and the development of neurodegeneration. Potentiation of α7 nicotinic receptor, ...
Screening and characterization of molecules that modulate thebiological activity of IFNs-I
(Elsevier Science, 2016-06)
Type I Interferons (IFNs-I) are species-specific glycoproteins which play an important role as primary defence against viral infections and that can also modulate the adaptive immune system. In some autoimmune diseases, ...
Effect of dietary intake of phenolic compounds from mango peel extract on growth, lipid peroxidation and antioxidant enzyme activities in zebrafish (Danio rerio)Effect of dietary intake of phenolic compounds from mango peel extract on growth, lipid peroxidation and antioxidant enzyme activities in zebrafish (Danio rerio)
(Pontificia Universidad Católica de Valparaíso, 2019)
Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective
(Pergamon-Elsevier Science Ltd, 2016-08)
Enhancement of α7 nicotinic receptor (nAChR) function by positive allosteric modulators (PAMs) is a promising therapeutic strategy to improve cognitive deficits. PAMs have been classified only on the basis of their macroscopic ...
Action modes of the immune modulating activities of crude mushroom polysaccharide from Phallus atrovolvatus
(Elsevier, 2020-07)
Phallus atrovolvatus is a wild edible mushroom which is recently being cultivated in Thailand. It contains a remarkable amount of β-(1,3–1,6)-glucan, a compound known for its immune modulating properties. Crude mushroom ...