Now showing items 1-10 of 159
The unfolded protein response: at the intersection between endoplasmic reticulum function and mitochondrial bioenergetics
(Frontiers Media, 2017)
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This ...
Mitochondria fine-tune the slow Ca2+ transients induced by electrical stimulation of skeletal myotubes
(Elsevier Ltd, 2010)
Mitochondria sense cytoplasmic Ca2+ signals in many cell types. In mammalian skeletal myotubes, depolarizing stimuli induce two independent cytoplasmic Ca2+ signals: a fast signal associated with contraction and a slow ...
Skeletal muscle excitation-metabolism coupling
(Academic Press Inc., 2019)
Mitochondria represent the main source of ATP in skeletal muscle and mitochondria activity increases after muscle fiber depolarization. The regulation of mitochondrial function during contraction in skeletal muscle, however, ...
Mitochondria and calcium regulation as basis of neurodegeneration associated with aging
(Frontiers Media S.A., 2018)
© 2018 Müller, Ahumada-Castro, Sanhueza, Gonzalez-Billault, Court and Cárdenas.Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several ...
ER-to-mitochondria miscommunication and metabolic diseases
© 2015 Elsevier B.V.. Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic ...
Mitochondria in structural and functional cardiac remodeling
(Springer New York LLC, 2017)
© 2017, Springer International Publishing AG. The heart must function continuously as it is responsible for both supplying oxygen and nutrients throughout the entire body, as well as for the transport of waste products to ...
Parkin gone wild: Unbridled ubiquitination
(Lippincott Williams and Wilkins, 2015)
Parkin Gone Wild Unbridled Ubiquitination
(Lippicott Williams & Wilkins, 2015)
Nutritional effects on mitochondrial bioenergetics. Alterations in calcium uptake by rat liver mitochondria.
The uptake of Ca2+ by energized liver mitochondria was compared in normal fed as well as in protein-energy malnourished rats. In the presence of phosphate, mitochondria obtained from both groups were able to accumulate ...
Characterization of mitochondrial iron uptake in HepG2 cells
There is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreichâ€™s ataxia and Parkinsonâ€™s disease. ...