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A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2014)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(2013-01-01)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2015)
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2015)
Effect of forage species and supplement type on rumen kinetics and serum metabolites in developing beef heifers grazing winter forage.
(Amer Soc Animal Science, 2017-08-01)
Enantioselective analysis of zopiclone and its metabolites in plasma by liquid chromatography/tandem mass spectrometry
(SPRINGER HEIDELBERG, 2011)
A high-performance liquid chromatographic method with triple-quadrupole mass spectrometry detection (LC-MS-MS) was developed and validated for the first time for the simultaneous quantification of zopiclone and its metabolites ...
A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans
(Public Library Science, 2015-03-10)
For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none ...
In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction
(SPRINGER FRANCE, 2011)
Rosiglitazone (RSG), a thiazolidinedione antidiabetic drug, is metabolized by CYP450 enzymes into two main metabolites: N-desmethyl rosiglitazone (N-Dm-R) and rho-hydroxy rosiglitazone (rho-OH-R). In humans, CYP2C8 appears ...
BIODEGRADATION KINETICS OF 4-CHLOROPHENOL, AN INHIBITORY CO-METABOLITE
(WATER ENVIRONMENT FEDERATION, 1991)
Kinetic experiments were performed with batch reactors containing a pure culture of Psedomonas putida PpG4 and 4-chlorophenol as the only organic substrate present. 4-Chlorophenol behaved as a cometabolite because its ...
Modelling Gibberella fujikuroi growth and GA(3) production in solid-state fermentation
(ELSEVIER SCI LTD, 2002)
A simple differential equation model was developed to represent the growth and production of a secondary metabolite in solid-state cultivation (SSC) under conditions of limited nitrogen. The model was used to interpret ...