Every biological tissue or physical system is subject to physical restrictions that limit its functioning. Specifically in neural networks, energy constraints determine physically feasible states in which they can evolve. ...

The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These ...

Meat quality and mineral composition are complex traits genetically regulated. Growing evidence suggests that minerals play a central role in regulatory and physiological functions related to meat tenderness and fat ...

In the first chapter, this thesis aims to demonstrate the great potential of Constraint-Based Reconstruction and Analysis (COBRA) methods for studying and predicting specific phenotypes in the bacterium Acidithiobacillus ...

Saprobic fungus are being used as an alternative strategy to reduce the use of pesticides harmful to the environment. These microorganisms produce substances capable of inhibiting pathogens that affect agriculture. The ...

The supply of oxygen as a limiting nutrient in bioreactors is a challenge, as microorganisms may have different metabolic requirements, besides the difficulty of measuring this variable in low levels. Despite the obstacles, ...

Esta tesis presenta contribuciones para la reconstrucción a escala del genoma de las redes metabólicas y sus restricciones basadas en análisis. Se presenta una breve descripción general del modelado y la reconstrucción de ...