Search
Now showing items 1-10 of 83
Improving the Therapeutic Ability of Mesenchymal Stem/Stromal Cells for the Treatment of Conditions Influenced by Immune Cells
(Hindawi Publishing Corporation, 2021-02)
Currently, mesenchymal stem/stromal cells (MSCs) are among the most used cells in clinical trials. Whereas many characteristics of these cells have been described to date, aspects of their basic biology that may have an ...
Improving the Therapeutic Ability of Mesenchymal Stem/Stromal Cells for the Treatment of Conditions Influenced by Immune Cells
(Hindawi Publishing Corporation, 2019-12)
Mesenchymal stem/stromal cells (MSCs) have been initially described decades ago as fibroblastic precursors that could be isolated from the bone marrow and establish cultures of fibroblastic cells. These fibroblastic cells ...
High RAC3 expression levels are required for induction and maintaining of cancer cell stemness
(Impact Journals, 2017-12)
RAC3 is a transcription coactivator, usually overexpressed in several tumors and required to maintain the pluripotency in normal stem cells. In this work we studied the association between RAC3 overexpression on cancer ...
Design and characterization of microspheres for a 3D mesenchymal stem cell culture
(Elsevier Science, 2020-12)
Recent studies have shown the relevance of growing mesenchymal stem cells (MSCs) in three-dimensional environments with respect to the monolayer cell culture on an adherent substrate. In this sense, macroporous scaffolds ...
Characterization of Tunneling Nanotubes in Wharton’s jelly Mesenchymal Stem Cells. An Intercellular Exchange of Components between Neighboring Cells
(Springer Heidelberg, 2017-08)
Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT ...
A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement
(BioMed Central Ltd., 2015-01)
Introduction: Mesenchymal stem cells (MSCs) are a promising source of cells for regenerative therapies. Although they can be isolated easily from several tissues, cell expansion is limited since their properties are lost ...
Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro
(Elsevier, 2020-11)
Cellular therapy with mesenchymal stem cells (MSC) is emerging as an effective option to treat optic neuropathies. In models of retinal degeneration, MSC injected in the vitreous body protects injured retinal ganglion cells ...
A protocol for umbilical cord tissue cryopreservation as a source of mesenchymal stem cells
(Springer, 2021-01)
Mesenchymal stem cells (MSC) differentiate into different cell types and have immunomodulatory and paracrine effects. Cryopreservation of umbilical cord tissue as a source of MSC is very promising for regenerative medicine. ...
Modulation of adipose-derived mesenchymal stem/stromal cell transcriptome by G-CSF stimulation
(Hindawi Publishing Corporation, 2020-01)
Mesenchymal stem/stromal cells (MSCs) exhibit multidifferentiation potential, paralleled with immunomodulatory and trophic properties that make them viable alternative tools for the treatment of degenerative disorders, ...
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment
(Public Library of Science, 2019-12-27)
Kaposi’s sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). Unanswered questions regarding KS are its cellular ontology and the conditions conducive to viral oncogenesis. We identify ...