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Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy
(BioMed Central Ltd., 2017)
© 2017 The Author(s). Background: The liver has the remarkable capacity to regenerate in order to compensate for lost or damaged hepatic tissue. However, pre-existing pathological abnormalities, such as hepatic steatosis ...
Efficient isolation and proliferation of human adipose-derived mesenchymal stromal cells in xeno-free conditions
(2020-04-01)
Classical methods used for culture of adipose-derived mesenchymal stromal cells (ADSCs) use xenobiotic components, which may present a potential risk for biological contamination and/or elicit immunological reactions. ...
Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice
(BioMed Central, 2016)
Diabetic retinopathy is a common complication of diabetes and the leading cause of irreversible vision loss in the Western world. The reduction in color/contrast sensitivity due to the loss of neural cells in the ganglion ...
Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?
Mesenchymal stromal cells (MSC) have immune regulatory and tissue regenerative
properties. MSCs are being studied as a therapy option for many inflammatory and
immune disorders and are approved to treat acute graft-versus-host ...
Novel aspects of parenchymal–mesenchymal interactions: from cell types to molecules and beyond
(Wiley, 2013-06)
Mesenchymal stem or stromal cells (MSCs) were initially isolated from the bone marrow and received their name on the basis of their ability to differentiate into multiple lineages such as bone, cartilage, fat and muscle. ...
Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells
(2014)
Human adipose‐derived mesenchymal stromal cells (AMSCs) grown in platelet lysate are promising agents for therapeutic tissue regeneration. Here, we investigated whether manipulation of epigenetic events by the clinically ...
Mesenchymal stem cells and their use in therapy: What has been achieved?
(Elsevier, 2013-01-31)
The considerable therapeutic potential of human multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) has generated increasing interest in a wide variety of biomedical disciplines. Nevertheless, researchers ...
Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy
(BioMed Central, 2017)
Background: The liver has the remarkable capacity to regenerate in order to compensate for lost or damaged
hepatic tissue. However, pre-existing pathological abnormalities, such as hepatic steatosis (HS), inhibits the ...