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Filling gaps in the knowledge of melittin on lipid membranes
(Elsevier Science, 2019-01-21)
Melittin (ML) is a small peptide of 26 residues rich in arginine (Arg) and lysine (Lys). Several studies have been done to understand the mechanism of interaction with neutral and negatively charged lipids. However, it is ...
Control of membrane lipid homeostasis by lipid-bilayer associated sensors: A mechanism conserved from bacteria to humans
(Pergamon-Elsevier Science Ltd, 2019-10)
The lipid composition of biological membranes is key for cell viability. Nevertheless, and despite their central role in cell function, our understanding of membrane physiology continues to lag behind most other aspects ...
L-ascorbic acid alkyl esters action on stratum corneum model membranes: an insight into the mechanism for enhanced skin permeation
(Elsevier Science, 2019-11)
L-ascorbic acid alkyl esters (ASCn) are lipophilic forms of vitamin C, which act as skin permeation enhancers. We investigated the physical changes induced by incorporating ASCn into stratum corneum (SC) lipid membranes ...
How membrane lipids control the 3D structure and function of receptors
(American Institute of Mathematical Sciences, 2018-03)
The cohabitation of lipids and proteins in the plasma membrane of mammalian cells is controlled by specific biochemical and biophysical rules. Lipids may be either constitutively tightly bound to cell-surface receptors ...
Lipid hydroperoxidation effect on the dynamical evolution of the conductance process in bilayer lipid membranes: A condition toward criticality
(American Chemical Society, 2020-08-04)
Cell membranes are one of the main targets of oxidative processes mediated by reactive oxygen species (ROS). These chemical species interact with unsaturated fatty acids of membrane lipids, triggering an autocatalytic chain ...
Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol
(Elsevier Science, 2013-11)
Large procyanidins (more than three subunits) are not absorbed at the gastrointestinal tract but could exert local effects through their interactions with membranes. We previously showed that hexameric procyanidins (Hex), ...
Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance
(Royal Society of Chemistry, 2015-01)
Flavonoids are a type of phenolic compound widely present in edible plants. A great number of health benefits have been ascribed to flavonoid consumption in the human population. However, the molecular mechanisms involved ...
Breakdown of classical paradigms in relation to membrane structure and functions
(Elsevier Science, 2021-02)
Updates of the mosaic fluid membrane model implicitly sustain the paradigms that bilayers are closed systems conserving a state of fluidity and behaving as a dielectric slab. All of them are a consequence of disregarding ...
Fluorescence sensors for imaging membrane lipid domains and cholesterol
(Elsevier Academic Press Inc., 2021-10)
Lipid membrane domains are supramolecular lateral heterogeneities of biological membranes. Of nanoscopic dimensions, they constitute specialized hubs used by the cell as transient signaling platforms for a great variety ...
Effect of N-terminal acetylation on lytic activity and lipid-packing perturbation induced in model membranes by a mastoparan-like peptide
(Elsevier Science, 2018-03)
L1A (IDGLKAIWKKVADLLKNT-NH2) is a peptide that displays a selective antibacterial activity to Gram-negative bacteria without being hemolytic. Its lytic activity in anionic lipid vesicles was strongly enhanced when its ...