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Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice
(Pergamon-Elsevier Science Ltd., 2001)
Expansion of CD11b+Ly6G +Ly6Cint cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions
(Springer, 2013-10-11)
The progesterone analog medroxyprogesterone acetate (MPA) is widely used as a hormone replacement therapy in postmenopausal women and as contraceptive. However, prolonged administration of MPA is associated with increased ...
In vitro effects of progesterone and the synthetic progestin medroxyprogesterone acetate on vascular remodeling
(Elsevier Science, 2019-08-01)
In this work we tested the hypothesis whether progesterone (Pg)or the synthetic progestin medroxyprogesterone acetate (MPA) could beinvolved in the regulation of events involved in vascular remodeling.Results revealed an ...
Hormone-independent mouse mammary adenocarcinomas with different metastatic potential exhibit different metabolic signatures
(MDPI AG, 2020)
The metabolic characteristics of metastatic and non-metastatic breast carcinomas remain poorly studied. In this work, untargeted Nuclear Magnetic Resonance (NMR) metabolomics was used to compare two medroxyprogesterone ...
Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma
(Kluwer Academic/plenum Publ, 2003-05)
The purpose of this study was to evaluate the effect of the selective estrogen receptor modulators raloxifene and tamoxifen and of the pure antiestrogen fulvestrant on tumor growth and progesterone receptor (PR) expression ...
Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer
(BioScientifica, 2018-12)
There is a consensus that progestins and thus their cognate receptor molecules, the progesterone receptors (PRs), are essential in the development of the adult mammary gland and regulators of proliferation and lactation. ...
Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs
(Korean Society of Veterinary Science, 2016-03)
To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n ...
Vaginal histological changes after using intravaginal sponges for oestrous synchronization in anoestrous ewes
(Wiley, 2015-04)
To characterize the histological and cytological vaginal changes generated by the use of intravaginal sponge (IS) applied in oestrous synchronization treatments in ewes during mid‐non‐breeding season. Thirty‐five multiparous ...
Metabolic adaptations in an endocrine-related breast cancer mouse model unveil potential markers of tumor response to hormonal therapy
(Frontiers Media, 2022-03)
Breast cancer (BC) is the most common type of cancer in women and, in most cases, it is hormone-dependent (HD), thus relying on ovarian hormone activation of intracellular receptors to stimulate tumor growth. Endocrine ...
196 Fertilization Rate in Superovulated Criolla Goats Following Artificial Insemination or Natural Mating
(Csiro Publishing, 2017-12-04)
The Criolla breed is a local genetic resource, distributed in Patagonia, Argentina, whose primary production is meat. In the Criolla goat, efforts were made to locate productively superior males and to conserve their genetic ...