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Mechanism of action of drugs with activity against multicellular parasites
(Nauka, 2017-03)
Parasiticides have been the most valuable weapons to combat parasites for almost half a century, constituting more than 50 % of veterinary pharmaceuticals and a good part of the products destined for human health. However, ...
Rezafungin—mechanisms of action, susceptibility and resistance: Similarities and differences with the other echinocandins
(MDPI AG, 2020-12)
Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-acting echinocandins. It has several advantages ...
Plant antifungal lectins: Mechanism of action and targets on human pathogenic fungi
(Bentham Science Publishers, 2019-09)
Lectins are proteins characterized by their ability to specifically bind different carbohydrate motifs. This feature is associated with their endogenous biological function as well as with multiple applications. Plants are ...
Nanostructured alumina: biocidal properties and mechanism of action of a novel insecticide powder
(Alma Mater Studiorum, Univ Bologna, 2017-07)
Pest control using synthetic chemical pesticides is facing economic and environmental challenges worldwide. In this context, nanomaterials, emerge as potential tools that need to be investigated. The aim of this study was ...
Lagrangian reduction of nonholonomic discrete mechanical systems
(American Institute of Mathematical Sciences, 2010-03)
In this paper we propose a process of lagrangian reduction and<br />reconstruction for nonholonomic discrete mechanical systems where the action of a continuous symmetry group makes the configuration space a principal ...
The dual role of evo-devo mechanisms and the extended evolutionary synthesis
(Universidad Federal de Santa Catarina, 2018-08)
The distinction between mechanisms that generate biological variation and mechanisms that modify it has been important in contemporary Biology, especially since the establishment of the Evolutionary Synthesis (ES) in the ...
Antifungal activity of Zuccagnia punctata Cav.: Evidence for the mechanism of action
(Georg Thieme Verlag Kg, 2007-08)
Petroleum ether and dichloromethane extracts of fruits, aerial parts and exudate of Zuccagnia punctata Cav. (Fabaceae) showed moderate antifungal activities against the yeasts C. albicans, S. cerevisiae and C. neoformans ...
Antifungal modes of action of Saccharomyces and other biocontrol yeasts against fungi isolated from sour and grey rots
(Elsevier Science, 2015-07-02)
The aim of this study was to determine the putative modes of action of 59 viticultural yeasts (31 Saccharomyces and 28 non- Saccharomyces) that inhibited fungi isolated from sour and grey rot in grapes. Inhibition of fungal ...
Azilsartan and its Zn(II) complex. Synthesis, anticancer mechanisms of action and binding to bovine serum albumin
(Pergamon-Elsevier Science Ltd, 2018-04)
Azilsartan is the eighth approved member of angiotensin II receptor blockers for hypertension treatment. Considering that some drugs have additional effects when administered, we studied its effects and mechanisms of action ...
The case for class II bacteriocins: A biophysical approach using “suicide probes” in receptor-free hosts to study their mechanism of action
(Elsevier B.V., 2019-10)
Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization ...