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Evaluation of melatonin effect on human breast cancer stem cells using a threedimensional growth method of mammospheres
(2017-01-01)
Background: The high rates of women's death from breast cancer occur due to acquired resistance by patients to certain treatments, enabling the recurrence and/or tumor growth, invasion and metastasis. It has been demonstrated ...
Melatonin decreases estrogen receptor binding to estrogen response elements sites on the oct4 gene in human breast cancer stem cells
(2016-05-01)
Cancer stem cells (CSCs) pose a challenge in cancer treatment, as these cells can drive tumor growth and are resistant to chemotherapy. Melatonin exerts its oncostatic effects through the estrogen receptor (ER) pathway in ...
Cancer Stem And Progenitor-like Cells As Pharmacological Targets In Breast Cancer Treatment
(LIBERTAS ACADAUCKLAND, 2015)
Tamoxifen selects for breast cancer cells with mammosphere forming capacity and increased growth rate.
(Springer, 2013-12)
Using the M05 mouse mammary tumor model and the MCF-7 cell line, we investigated the effect of tamoxifen treatment on the fraction of breast cancer cells with self-renewing capacity both in vitro and in vivo. We found that ...
Isolamento e caracterização de células-tronco/progenitoras a partir de cultivo in vitro de linhagens celulares de carcinoma de mama humana
(Universidade Federal de Minas GeraisUFMG, 2013-03-08)
Breast cancer is the second most common type of cancer worldwide and the most common among women. It is a heterogeneous disease, possibly due to the existence of a small population of cells in these tumors with stem cell ...
Histamine H4 receptor agonists induce epithelial-mesenchymal transition events and enhance mammosphere formation via Src and TGF-β signaling in breast cancer cells
(Pergamon-Elsevier Science Ltd, 2020-10)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer ...
Endocrine disruptor chlorpyrifos promotes migration, invasion, and stemness phenotype in 3D cultures of breast cancer cells and induces a wide range of pathways involved in cancer progression
(Academic Press Inc Elsevier Science, 2021-03)
Organophosphorus chlorpyrifos (CPF) is currently considered an endocrine disruptor (ED), as it can imitate hormone actions both in vitro and in vivo. We recently reported that CPF induces migration and invasion in 2D ...
Anticancer and Antimetastatic Activity of Copper(II)-tropolone complex against human breast cancer cells, breast multicellular spheroids and mammospheres
(Elsevier Science Inc, 2020-03)
The goal of this work was to display the anticancer and antimetastatic activity of a copper(II) with tropolone (trp), complex [Cu(trp)2] toward human breast cancer cells in monolayer (2D) and spheroids (3D). Cytotoxicity ...
Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells Through the Activation of the MAPK/ERK Pathway
(Korean Cancer Association, 2016-12)
PURPOSE: We investigated the effects of laminin on the fraction of cells with self-renewing capacity in the estrogen-dependent, tamoxifen-sensitive LM05-E breast cancer cell line. We also determined whether laminin affected ...