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A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages

Catalan-Figueroa, Johanna; Boisset, Constanza B.; Jara, Miguel O.; Flores, Mario E.; Moreno-Villoslada, Ignacio; Fiedler, Jenny L.; Morales, Javier O. (Elsevier B.V., 2018)

© 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...