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Synthesis of: N -acetylglucosamine and N -acetylallosamine resorcinarene-based multivalent β-thio-glycoclusters: Unexpected affinity of N -acetylallosamine ligands towards Wheat Germ Agglutinin
(Royal Society of Chemistry, 2020-09)
Herein, we report the synthesis of calix[4]resorcinarene-based multivalent ligands bearing β-S-GlcNAc and β-S-AllNAc recognition elements. A clickable β-S-AllNAc derivative was successfully prepared from a β-thioalkynyl ...
Design and synthesis of hydrolytically stable multivalent ligands bearing thiodigalactoside analogues for peanut lectin and human galectin-3 binding
(American Chemical Society, 2014-06-17)
Herein, we describe the design and synthesis of a novel family of hydrolytically stable glycoclusters bearing thiodigalactoside (TDG) analogues as recognition elements of b-galactoside binding lectins. The TDG analogue was ...
Multivalent sialylation of beta-thio-glycoclusters by Trypanosoma cruzi trans sialidase and analysis by High Performance Anion Exchange Chromatography
(Springer, 2016-10)
The synthesis of multivalent sialylated glycoclusters is herein addressed by a chemoenzymatic approach using the trans-sialidase of Trypanosoma cruzi (TcTS). Multivalent β-thio-galactopyranosides and β-thio-lactosides were ...
Synthesis of multivalent glycoclusters from 1-thio-β-D-galactose and their inhibitory activity against the β-galactosidase from E. coli
(American Chemical Society, 2011-05)
The synthesis of multivalent glycoclusters, designed to be compatible with biological systems, is reported. A variety of 1-thio-β-d-galactosides linked to a terminal triple bond through oligoethyleneglycol chains of variable ...
Multivalent interaction of cyclodextrin vesicles, carbohydrate guests, and lectins: A kinetic investigation
(American Chemical Society, 2011-02)
An artificial glycocalix self-assembles when unilamellar bilayer vesicles of amphiphilic β-cyclodextrins are decorated with maltose-and lactose-adamantane conjugates by host-guest interactions. The maltose-decorated vesicles ...
Synthesis and biological activity of divalent ligands based on 3-deoxy-4-thiolactose, an isosteric analogue of lactose
(Royal Society of Chemistry, 2013)
Synthesis of divalent ligands of beta-thio- and beta-N-galactopyranosides and related lactosides and their evaluation as substrates and inhibitors of Trypanosoma cruzi trans-sialidase
(Beilstein-institut, 2014-12)
In this work we describe the synthesis of mono- and divalent β-N- and β-S-galactopyranosides and related lactosides built on sugar scaffolds and their evaluation as substrates and inhibitors of the Trypanosoma cruzi ...
Crystal structures of peanut lectin in the presence of synthetic β-N- And β-S-galactosides disclose evidence for the recognition of different glycomimetic ligands
(International Union of Crystallography, 2020-11)
Carbohydrate-lectin interactions are involved in important cellular recognition processes, including viral and bacterial infections, inflammation and tumor metastasis. Hence, structural studies of lectin-synthetic glycan ...
Ligandos multivalentes con residuos de tioazúcares. Síntesis y actividad biológicaMultivalent ligands bearing thiosugars. Synthesis and biological activity
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2013)
Hierarchical Multivalent Effects Control Influenza Host Specificity
(American Chemical Society, 2020-11)
Understanding how emerging influenza viruses recognize host cells is critical in evaluating their zoonotic potential, pathogenicity, and transmissibility between humans. The surface of the influenza virus is covered with ...