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Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine: Impact on its function as membrane barrier
(Academic Press Ltd - Elsevier Science Ltd, 2016-07)
The gastrointestinal epithelium functions as a selective barrier to absorb nutrients, electrolytes and water, but at the same time restricts the passage into the systemic circulation of intraluminal potentially toxic ...
Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines
(Public Library Of Science, 2015-03-19)
Cyclic AMP represents one of the most studied signaling molecules and its role in proliferation and differentiation processes has been well established. Intracellular cAMP levels are tightly regulated where the MRP4 ...
Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity
(Elsevier Ireland, 2014-04)
ABC transporters including MRP2, MDR1 and BCRP play a major role in tissue defense. Epidemiological and experimental studies suggest a cytoprotective role of estrogens in intestine,though the mechanism remains poorly ...
Role of interleukin 1 beta in the regulation of rat intestinal Multidrug resistance-associated protein 2 under conditions of experimental endotoxemia
(Elsevier Ireland, 2020-08)
Multidrug resistance-associated protein 2 (Mrp2), expressed at the brush border membrane (BBM) of the enterocyte, is an ABC transporter with relevant intestinal barrier function. Its toxicological relevance lies in preventing ...
Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
(Universidad Nacional de La Plata. Facultad de Medicina. Centro de Investigaciones Cardiovasculares, 2014-12)
The liver is the main place for phase II metabolism and transport of xenobiotics mediated by Mrp2, leading to elimination of conjugated metabolites into bile. In the gastrointestinal tract, phase II enzymes and Mrp2 are ...
Rol de adenosina en la quimioresistencia de Glioblastoma stem-like cekks bajo condiciones de hipoxia.Role of adenosine in chemoresistance of Glioblastoma stem-like cells under hypoxia conditions.
(2019)
Glioblastoma (GBM) corresponde al tipo de tumor primario cerebral más común y agresivo. Aunque GBM cuenta con tratamientos bien establecidos, la sobrevida en Chile de estos pacientes no supera los 6 meses debido a que este ...
MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux
(Wiley Blackwell Publishing, Inc, 2020-05)
Intracellular cAMP (i-cAMP) levels play an important role in acute myeloid leukemia (AML) cell proliferation and differentiation. Its levels are the result of cAMP production, degradation, and exclusion. We have previously ...
MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux
(Wiley Blackwell Publishing, Inc, 2020-04)
Intracellular cAMP (i-cAMP) levels play an important role in acute myeloid leukemia (AML) cell proliferation and differentiation. Its levels are the result of cAMP production, degradation, and exclusion. We have previously ...