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The role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: Evidence from calretinin and neo-timm staining in pilocarpine-epileptic mice
(Lippincott Williams & Wilkins, 2000-01-01)
Mossy fiber sprouting is a major anatomical reorganization seen in patients with temporal lobe epilepsy and animal models of epilepsy. the final outcome of this reorganization is viewed by many as epileptogenic. Yet, ...
Hippocampal Mossy Cells Provide a Fate Switch for Adult Neural Stem Cells
(Cell Press, 2018-08)
The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells ...
Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus
(Wiley-Blackwell, 2000-01-01)
Dentate granule cells are generally considered to be relatively resistant to excitotoxicity and have been associated with robust synaptogenesis after neuronal damage. Synaptic reorganization of dentate granule cell axons, ...
Mesial temporal lobe epilepsy: Clinical and neuropathologic findings of familial and sporadic forms
(BLACKWELL PUBLISHING, 2008)
Purpose: To evaluate the clinical and hippocampal histological features of patients with mesial temporal lobe epilepsy (MTLE) in both familial (FMTLE) and sporadic (SMTLE) forms. Methods: Patients with FMTLE (n = 20) and ...
Neurophotonics Approaches for the Study of Pattern Separation
(Frontiers Media, 2020-06)
Successful memory involves not only remembering over time but also keeping memories distinct. Computational models suggest that pattern separation appears as a highly efficient process to discriminate between overlapping ...
Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death
(Associação Brasileira de Divulgação Científica, 2008-05-01)
Intrahippocampal administration of kainic acid (KA) induces synaptic release of neurotrophins, mainly brain-derived neurotrophic factor, which contributes to the acute neuronal excitation produced by the toxin. Two protein ...
DECREASED NEURON LOSS AND MEMORY DYSFUNCTION IN PILOCARPINE-TREATED RATS PRE-EXPOSED TO HYPOXIA
(Elsevier B.V., 2016-09-22)
Preconditioning can induce a cascade of cellular events leading to neuroprotection against subsequent brain insults. In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent ...
Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats
(2010)
There is no established treatment for the long-term effects produced by perinatal asphyxia. Thus, we investigated the neuroprotection provided by nicotinamide against the effects elicited by perinatal asphyxia on hippocampus ...
Response Surface Methodology for Optimization of Lipase Production by an Immobilized Newly Isolated Penicillium sp.
(Amer Chemical SocWashingtonEUA, 2008)
CIRCUIT MECHANISMS of SEIZURES in the PILOCARPINE MODEL of CHRONIC EPILEPSY - CELL LOSS and MOSSY FIBER SPROUTING
(Lippincott-raven Publ, 1993-11-01)
We used the pilocarpine model of chronic spontaneous recurrent seizures to evaluate the time course of supragranular dentate sprouting and to assess the relation between several changes that occur in epileptic tissue with ...