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Therapeutic targets in chagas disease
(2017-01-01)
Optimal pharmacotherapy occurs when we have selectivity and no toxicity. The discovery of specific pathways or enzymes that are vital forcell or parasite survival is also vital for the design of new specific, non-toxic ...
POTENTIAL MOLECULAR TARGETS FOR ANTITUBERCULOSIS DRUG DISCOVERY
(Soc Brasileira Quimica, 2017-06-01)
Tuberculosis (TB) is an infectious disease caused by mycobacteria from the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization (WHO) aims to reduce the number of TB cases worldwide ...
Potential molecular targets for antituberculosis drug discoveryPotenciais alvos moleculares para o desenvolvimento de novos fÁrmacos antituberculose
(2017-06-01)
Tuberculosis (TB) is an infectious disease caused by mycobacteria from the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization (WHO) aims to reduce the number of TB cases worldwide ...
In silico structural characterization of protein targets for drug development against Trypanosoma cruzi
(Springer Verlag (Germany), 2017)
Clear Shot at Primary Aim: Susceptibility of Trypanosoma cruzi Organelles, Structures and Molecular Targets to Drug Treatment
(Bentham Science Publishers, 2017)
Artificial Itelligence Teaches Drugs to Target Proteins by Tackling the Induced Folding Problem
(American Chemical Society, 2020-06-17)
We explore the possibility of a deep learning (DL) platform that steers drug design to target proteins by inducing binding-competent conformations. We deal with the fact that target proteins are usually not fixed targets ...
Selection of targets for drug development against protozoan parasites
(Bentham Science Publishers Ltd, 2014)