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MLL2/KMT2D and MLL3/KMT2C expression correlates with disease progression and response to imatinib mesylate in chronic myeloid leukemia
(BioMed Central, 2018)
Abstract
Background
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis is linked to the Philadelphia chromosome presence that generates ...
Unraveling the role of the tyrosine tetrad from the binding site of the epigenetic writer MLL3 in the catalytic mechanism and methylation multiplicity
(MDPI, 2022)
MLL3, also known as KMT2C, is a lysine mono-methyltransferase in charge of the writing of an epigenetic mark on lysine 4 from histone 3. The catalytic site of MLL3 is composed of four tyrosines, namely, Y44, Y69, Y128, and ...
Alterações epigenéticas induzidas pelo IFN-y e envolvidas na diferenciação de células dendríticas derivadas de monócitos (Mo-DCs) durante a malária
(Universidade Federal de Minas GeraisUFMG, 2018-05-25)
In infectious diseases such as malaria, monocytes, macrophages and dendritic cells are cellular populations that have crucial role in tissue repair, detection of presence of invading micro-organisms, initiating protective ...
Intiñan trivia
(2023)