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Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complex
(American Crystallographic Association, 2015-05)
Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug design often involves the use of synthetic peptides which contain ...
A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
(Cevap-sao Paulo State Univ-unesp, 2022-03-14)
Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects ...
Identification of a novel melittin isoform from Africanized Apis mellifera venom
(Elsevier B.V., 2010-08-01)
Apis mellifera, the European honey bee, is perhaps the most studied insect in the Apidae family. Its venom is comprised basically of melittin, phospholipase A(2), histamine, hyaluronidase, cathecolamines and serotonin. ...
Identification of a novel melittin isoform from Africanized Apis mellifera venom
(Elsevier B.V., 2010-08-01)
Apis mellifera, the European honey bee, is perhaps the most studied insect in the Apidae family. Its venom is comprised basically of melittin, phospholipase A(2), histamine, hyaluronidase, cathecolamines and serotonin. ...
Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response
(2016-01-08)
Background: Apis mellifera venom, which has already been recommended as an alternative anti-inflammatory treatment, may be also considered an important source of candidate molecules for biotechnological and biomedical uses, ...
In-depth characterization of antibacterial activity of melittin against Staphylococcus aureus and use in a model of non-surgical MRSA-infected skin wounds
(Universidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ALIMENTOSFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASUFMG, 2021-01-01)
Filling gaps in the knowledge of melittin on lipid membranes
(Elsevier Science, 2019-01-21)
Melittin (ML) is a small peptide of 26 residues rich in arginine (Arg) and lysine (Lys). Several studies have been done to understand the mechanism of interaction with neutral and negatively charged lipids. However, it is ...
Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of melittin and phospholipase A(2) levels
(Pergamon-Elsevier B.V. Ltd, 2010-09-01)
Apis mellifera venom is comprised basically of melittin, phospholipase A(2), histamine, hyaluronidase, catecholamine and serotonin. Some of these components have been associated with allergic reactions, amongst several ...
Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of melittin and phospholipase A(2) levels
(Pergamon-Elsevier B.V. Ltd, 2010-09-01)
Apis mellifera venom is comprised basically of melittin, phospholipase A(2), histamine, hyaluronidase, catecholamine and serotonin. Some of these components have been associated with allergic reactions, amongst several ...
Influence of apitoxin and melittin from Apis mellifera bee on Staphylococcus aureus strains
(Elsevier B.V., 2020-04-01)
The antibacterial activities of apitoxin, a venom produced by Apis mellifera bee, and melittin, an antimicrobial peptide from apitoxin, were tested against planktonic and biofilm states of Staphylococcus aureus ...