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Neurotoxicity of some MAO Inhibitors in Adult Rat Hypothalamic Cell Culture
(Taylor & Francis Ltd, 2001-05-04)
Monoamine oxidase-A (MAO-A) (amiflamine (AMF)
and 4-methylthioamphetamine (MTA)) and MAO-B (Ldeprenyl)
inhibitors were found to be cytotoxic in a
concentration-dependent manner for RCHTcells derived
from adult rat ...
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors
(2010)
2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided insight ...
Selegilina reverte a piora da memória inuzida por Aβ25-35 em camundongos: envolvimento da atividade da MAO-B
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2013-02-28)
Alzheimer s disease (AD) is biochemically characterized by the occurrence of extracellular deposits of amyloid beta peptide (Aβ) and intracellular deposits of the hyperphosphorylated tau protein, which are causally related ...
Efeito de 2-aril(heteroaril)-4,5-diidro-1h-imidazóis sobre a atividade da enzima monoamina oxidase in vitro
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2008-08-05)
Monoamine oxidase (MAO) is a flavin adenine dinucleotide (FAD)-containing enzyme attached to the mitochondrial outer membrane of neurons, glia, and other cells. Its roles include regulation of the levels of biogenic and ...
Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives. Structure-activity relationships
(1997)
The monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives with different substituents at or around the para position of the aromatic ring were evaluated. In in vitro studies in which a crude ...
Coumarin-Rasagiline Hybrids as Potent and Selective hMAO-B Inhibitors, Antioxidants, and Neuroprotective Agents
(John Wiley and Sons Ltd, 2020)