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Genistein activates transcription factor EB and corrects Niemann–Pick C phenotype
(MDPI, 2021)
Niemann-Pick type C disease (NPCD) is a lysosomal storage disease (LSD) characterized by abnormal cholesterol accumulation in lysosomes, impaired autophagy flux, and lysosomal dysfunction. The activation of transcription ...
Late-in-life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts
(2021-01-01)
Protein quality control mechanisms decline during the process of cardiac aging. This enables the accumulation of protein aggregates and damaged organelles that contribute to age-associated cardiac dysfunction. Macroautophagy ...
Mononuclear phagocytes in the blood of turtles characterized by ultrastructural and cytochemical analyses and by phagocytic activity
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
Ultrastructural and cytochemical characteristics of mononuclear phagocyte cells in turtles are not well described in the literature, especially in Phrynops hilarii. Thus, the aim of this study was to evaluate these ...
Health status and bioremediation capacity of wild freshwater mussels (Diplodon chilensis) exposed to sewage water pollution in a glacial Patagonian lake
(Elsevier, 2014-03-01)
Deleterious effects on health and fitness are expected in mussels chronically exposed to sewage water pollution. Diplodon chilensis inhabiting SMA, an area affected by untreated and treated sewage water, shows increased ...
Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens
(Springer Wien, 2014-09)
Macroautophagy is a self-degradative process that normally maintains cellular homeostasis via a lysosomal pathway. It is induced by different stress signals, including nutrients and growth factors’ restriction as well as ...
Kidney Function and 24-Hour Proteinuria in Patients with Fabry Disease during 36 Months of Agalsidase Alfa Enzyme Replacement Therapy: A Brazilian Experience
(TAYLOR & FRANCIS INC, 2009)
Background. Prior to the introduction of enzyme replacement therapy (ERT), management of Fabry disease (FD) consisted of symptomatic and palliative measures. ERT has been available for several years using recombinant human ...
Hemin induces mitophagy in a leukemic erythroblast cell line
(Portland Press, 2016-04)
In eukaryotic cells, autophagy is considered a lysosomal catabolic process which participates in the degradation of intracellular components in a vacuolar structure termed autolysosome. This pathway plays a significant ...
Limited heme oxygenase contribution to modulating the severity of salmonella enterica serovar typhimurium infection
(MDPI, 2022)
An important virulence trait of Salmonella enterica serovar Typhimurium (S. Typhimurium) is the ability to avoid the host immune response, generating systemic and persistent infections. Host cells play a crucial role in ...
Bordetella parapertussis Survives inside Human Macrophages in Lipid Raft-Enriched Phagosomes
(American Society for Microbiology, 2014-08)
Bordetella parapertussis is a human pathogen that causes whooping cough. The increasing incidence of B. parapertussis has been attributed to the lack of cross protection induced by pertussis vaccines. It was previously ...