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Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia
(American Chemical Society, 2021-02)
Loperamide is a μ-opioid agonist with poor gastrointestinal absorption, mainly because of its modest aqueous solubility and being a P-glycoprotein (Pgp) efflux substrate. Nevertheless, studies associated with therapeutic ...
Cattle nematodes resistant to macrocyclic lactones: Comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin
(Academic Press Inc Elsevier Science, 2010-06)
The role of the drug efflux pump, known as P-glycoprotein, in the pharmacokinetic disposition (host) and resistance mechanisms (target parasites) of the macrocyclic lactone (ML) antiparasitic compounds has been demonstrated. ...
Inhibition of intestinal transit by methanolic extracts of Annona muricata L. sheets (Soursop) in miceInhibición del tránsito intestinal por el extracto metanólico de las hojas de Annona muricata L (guanábana) en ratones
(Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica, 2011)
Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep
(Elsevier Science, 2010-09)
The in vivo co-administration of ivermectin (IVM) with P-glycoprotein (P-gp) modulator agents has been shown to enhance its systemic availability. However, there is no sufficient evidence on the impact that this type of ...