The indiscriminate use of conventional antibiotics is leading to an increase in the number of resistant bacterial strains, motivating the search for new compounds to overcome this challenging problem. Antimicrobial peptides, ...

L1A (IDGLKAIWKKVADLLKNT-NH2) is a peptide that displays a selective antibacterial activity to Gram-negative bacteria without being hemolytic. Its lytic activity in anionic lipid vesicles was strongly enhanced when its ...

Linear antimicrobial peptides, short sequences up to 50 amino acids, rich in basic and hydrophobic residues, are able to form an amphipathic helix when adsorbed onto lipid membranes. Thanks to these characteristics they ...

Effects induced by the incorporation of lipid II (LII) molecule into phosphatidylglycerol (PG) membranes were studied by Raman microspectroscopy. Spectral behavior of multilayer vesicles in liquid crystalline and gel phases ...

Peptídeos antimicrobianos agem diretamente na matriz lipídica da membrana celular perturbando o empacotamento lipídico, criando tensões elásticas e desequilíbrio de massa, que são relaxados pela formação de poros ou defeitos ...

Viral membrane fusion is an orchestrated process triggered by membrane-anchored viral fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory syndrome (SARS) coronavirus (CoV) contains ...