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Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease: Proactive semantic interference versus standard neuropsychological assessments
(Elsevier Inc., 2018-11)
The main objective of this study was to assess cognitive and depressive manifestations associated with Alzheimer?s disease in middle-aged asymptomatic individuals with maternal versus paternal family history of the disease ...
White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2020-03)
Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer's disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with ...
White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2020-03)
Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer's disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with ...
Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer’s Disease
(IOS Press, 2017-10)
Background: We have obtained previous evidence of limbic dysfunction in middle-Aged, asymptomatic offspring of lateonset Alzheimer´s disease (LOAD) patients, and failure to recover from proactive semantic interference has ...
Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients
(Pergamon-Elsevier Science Ltd, 2019-05)
Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions ...
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases
(Pergamon-Elsevier Science Ltd, 2018-08)
Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or development of novel ...
Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without family history of late-onset alzheimer’s disease
(American Psychiatric Publishing, Inc, 2019-01)
Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to ...
Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2018-12)
The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the ...
Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease
(Elsevier, 2020-01)
Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
Effects of experimental intracerebral ventricular injection of amyloid beta peptide (1-42) aggregates on daily rhythms of Aβ-degrading enzymes in the hippocampus: Relevance to Alzheimer's disease pathophysiology
(Elsevier, 2019-09)
One of the main pathological features in the Alzheimer disease (AD) is the presence of senile plaques, primarily composed of Aβ peptide aggregates, in cortex and hippocampus. AD late onset, which constitutes 90% of cases, ...