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Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians

Faculdade de Medicina de São José do Rio Preto (FAMERP); Universidade de São Paulo (USP); Universidade Estadual Paulista (Unesp) (Associação Brasileira de Divulgação Científica (ABRADIC), 2003-07-01)

The genetic basis for dementias is complex. A common polymorphism in the apolipoprotein E (APOE) gene is considered to be the major risk factor in families with sporadic and late-onset Alzheimer's disease as well as in the ...

Assessment of risk factors for earlier onset of sporadic Alzheimer's disease dementia

Oliveira, Fabricio Ferreira de [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Chen, Elizabeth Suchi [UNIFESP]; Smith, Marilia de Arruda Cardoso [UNIFESP] (Medknow Publications & Media Pvt Ltd, 2014-11-01)

Background: Pharmacological treatment has mild effects for patients with Alzheimer's disease dementia (AD); therefore, the search for modifiable risk factors is an important challenge. Though risk factors for AD are widely ...

Effects of APOE haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in Alzheimer's disease

de Oliveira, Fabricio Ferreira [UNIFESP]; Pereira, Fernando Vieira [UNIFESP]; Kamikado Pivi, Glaucia Akiko [UNIFESP]; Smith, Marilia Cardoso [UNIFESP]; Ferreira Bertolucci, Paulo Henrique [UNIFESP] (Taylor & Francis Ltd, 2018)

Background: Illiteracy, high cerebrovascular risk and copies of APOE-E4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk ...

Longitudinal lipid profile variations and clinical change in Alzheimer's disease dementia

de Oliveira, Fabricio Ferreira [UNIFESP]; Chen, Elizabeth Suchi [UNIFESP]; Smith, Marilia Cardoso [UNIFESP]; Ferreira Bertolucci, Paulo Henrique [UNIFESP] (Elsevier Ireland Ltd, 2017)

Hypercholesterolemia and statin use have been unevenly associated with clinical change in Alzheimer's disease dementia. In this longitudinal study, 192 consecutive outpatients with late-onset Alzheimer's disease dementia ...

Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease

Giavarotti, Leandro; Simon, Karin A. [UNIFESP]; Azzalis, Ligia A. [UNIFESP]; Fonseca, Fernando L. A. [UNIFESP]; Lima, Alessandra F. [UNIFESP]; Freitas, Maria C. V. [UNIFESP]; Brunialti, Milena K. C. [UNIFESP]; Salomao, Reinaldo [UNIFESP]; Moscardi, Alcione A. V. S. [UNIFESP]; Montano, Maria B. M. M. [UNIFESP]; Ramos, Luiz R. [UNIFESP]; Junqueira, Virginia B. C. [UNIFESP] (Hindawi Publishing Corporation, 2013-01-01)

Alzheimer's disease (AD) is a late-onset, progressive degenerative disorder that affects mainly the judgment, emotional stability, and memory domains. AD is the outcome of a complex interaction among several factors which ...

Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study

Rasmussen, Lucas [UNIFESP]; Delabio, Roger; Horiguchi, Lie; Mizumoto, Igor; Terazaki, Carlos-Renato; Mazzotti, Diego [UNIFESP]; Bertolucci, Paulo-Henrique [UNIFESP]; Pinhel, Marcela-Augusta; Souza, Doroteia; Krieger, Henrique; Kawamata, Carlos; Minett, Thais; Smith, Marilia Cardoso [UNIFESP]; Payao, Spencer-Luiz (Ios Press, 2013-01-01)

Alzheimer's disease (AD) is a progressive neurodegenerative disease that takes the form of a local overexpression of cytokines and other inflammatory molecules. We investigated three single-nucleotide polymorphisms (SNP) ...

Late auditory event-related evoked potential (P300) in Down's syndrome patients

César, Carla Patricia Hernandez Alves Ribeiro [UNIFESP]; Caovilla, Heloisa Helena [UNIFESP]; Munhoz, Mário Sérgio Lei[UNIFESP]; Ganança, Maurcio Malavasi (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2010-03-01)

Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease. Aim: to evaluate the latencies and ...