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Genetically modified mouse models in studies of luteinising hormone action
(Elsevier Ireland, 2006-06-27)
Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone ...
Gonadotrophin-Inhibitory Hormone in the Cichlid Fish Cichlasoma dimerus: Structure, Brain Distribution and Differential Effects on the Secretion of Gonadotrophins and Growth Hormone
(Wiley Blackwell Publishing, Inc, 2016-05)
The role of gonadotrophin-inhibitory hormone (GnIH) in the inhibition of the reproductive axis has been well-established in birds and mammals. However, its role in other vertebrates, such as the teleost fish, remains ...
Noradrenaline Involvement in the Negative-Feedback Effects of Ovarian Steroids on Luteinising Hormone Secretion
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Noradrenaline has been shown to modulate the ovarian-steroid feedback on luteinising-hormone (LH) release. However, despite the high amount of evidence accumulated over many years, the role of noradrenaline in LH regulation ...
Ovarian-Steroid Modulation of Locus Coeruleus Activity in Female Rats: Involvement in Luteinising Hormone Regulation
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
The noradrenergic nucleus locus coeruleus (LC) has been reported to regulate luteinising hormone (LH) secretion in female rats. Both oestrogen and progestin receptors have been demonstrated in LC neurones, suggesting that ...
Prenatal maternal restraint stress exposure alters the reproductive hormone profile and testis development of the rat male offspring
(Taylor & Francis Ltd, 2013-02)
Several studies have demonstrated that the presence of stressors during pregnancy induces adverse effects on the neuroendocrine system of the offspring later in life. In the present work, we investigated the effects of ...
Prenatal maternal restraint stress exposure alters the reproductive hormone profile and testis development of therat male offspring
(Taylor & Francis Ltd, 2013-02-07)
Several studies have demonstrated that the presence of stressors during pregnancy induces adverse effects on the neuroendocrine system of the offspring later in life. In the present work, we investigated the effects of ...
Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
(Elsevier Ireland, 2007-01)
In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta subunits (hCG+ mice) and knockout (KO) ...
Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction
(Wiley, 2016)
Reproduction involves the integration of hormonal signals acting across multiple systems to generate a synchronised physiological output. A critical component of reproduction is the luteinising hormone (LH) surge, which ...
Menstrual irregularity: a possible clinical marker of metabolic dysfunction in women with class III obesity
(Informa Healthcare, 2010-10-01)
Purpose. To evaluate whether menstrual irregularity in morbidly obese women is indicative of metabolic dysfunction.Patients and Methods. Fifty-seven women with morbid obesity were evaluated. They were divided into two ...
What have gonadotrophin overexpressing transgenic mice taught us about gonadal function?
(Society for Reproduction and Fertility, 2005-09)
The two gonadotrophins, follicle-stimulating hormone and luteinising hormone, are pivotal regulators of the development and maintenance of normal fertility by maintaining testicular and ovarian endocrine function and ...