Now showing items 1-10 of 3241
A mechanistic stress model of protein evolution accounts for site-specific evolutionary rates and their relationship with packing density and flexibility
(BioMed Central, 2014-04)
BACKGROUND: Protein sites evolve at different rates due to functional and biophysical constraints. It is usually considered that the main structural determinant of a site’s rate of evolution is its Relative Solvent ...
Stress, sintomas físicos, psicológicos e enfrentamento de situações estressoras em profissionais da sáude que atuam em hospitais
(Universidade Estadual Paulista (UNESP), 2014)
Predicting Posttraumatic Stress Symptom Prevalence and Local Distribution after an Earthquake with Scarce Data
After a major earthquake, the assignment of scarce mental health emergency personnel to different geographic areas is crucial to the effective management of the crisis. The scarce information that is available in the ...
Thiol oxidation by nitrosative stress: Cellular localization in human spermatozoa
(Informa Healthcare, 2016-09)
Peroxynitrite is a highly reactive nitrogen species and when it is generated at high levels it causes nitrosative stress, an important cause of impaired sperm function. High levels of peroxynitrite have been shown to ...
Oxidative stress in the local and systemic events of apical periodontitis
(Frontiers Media SA, 2017)
Oxidative stress is involved in the pathogenesis of a variety of inflammatory disorders. Apical periodontitis (AP) usually results in the formation of an osteolytic apical lesion (AL) caused by the immune response to ...
Control of cardiovascular responses to stress by CRF in the bed nucleus of stria terminalis is mediated by local NMDA/nNOS/sGC/PKG signaling
The aims of the present study were to assess an interaction of corticotropin-releasing factor (CRF) neurotransmission within the bed nucleus of the stria terminalis (BNST) with local nitrergic signaling, as well as to ...
An engineering methodology to assess effects of weld strength mismatch on cleavage fracture toughness using the Weibull stress approach
This work describes the development of an engineering approach based upon a toughness scaling methodology incorporating the effects of weld strength mismatch on crack-tip driving forces. The approach adopts a nondimensional ...
Oxidative stress in tumor microenvironment -- Its role in angiogenesis
The tumor angiogenesis process is believed to be dependent on an "angiogenic switch" formed by a cascade of biologic events as a consequence of the "cross-talk" between tumor cells and several components of local ...
Determination of potential risk of heat stress of cattle in four locations of Central and Southern Chile
(Facultad de Ciencias Veterinarias, Universidad Austral de Chile, 2010)