Buscar
Mostrando ítems 1-10 de 39
Liver glucokinase: An overview on the regulatorymechanisms of its activity
(John Wiley & Sons Inc, 2011-01)
Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. ...
Control of liver glucokinase activity: a potential new target for incretin hormones?
(Elsevier Science Inc, 2015-12)
We tested the exendin-4 and des-fluoro-sitagliptin effects on fructose-induced increase in liver glucokinase activity in rats with impaired glucose tolerance and the exendin-4 effect on glucokinase activity in HepG2 cells ...
Adaptive character of liver glucokinase
(Kluwer Academic Publishers, 1975)
1. Glucokinase is one of four glucose phos-phorylating enzymes present in rat liver. Its distinctive features are a high Km for glucose (high-Km isozyme) and a rather narrow substrate specificity. In contrast, the other ...
Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme
(American Diabetes Association, 2005-10)
The glucokinase regulatory protein (GRP) plays a pivotal role in the regulation of metabolic flux in liver by the glucose-phosphorylating enzyme glucokinase. Random peptide phage display library screening for binding ...
Induction of glucokinase by glucose in rat liver
(1963)
EVIDENCE that the nature and amount of carbohydrates in the diet significantly influence the activity of several enzymes related to carbohydrate metabolism is now accumulating. Among other enzymes, glucokinase decreases ...
Regulation of liver glucokinase activity in rats with fructose-induced insulin resistance and impaired glucose and lipid metabolism
(National Research Council Canada-NRC Research Press, 2009-09)
We evaluated the relative role of different regulatory mechanisms, particularly 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFK2/FBPase-2), in liver glucokinase (GK) activity in intact animals with fructose-induced ...
The kinetic properties of liver glucokinase and its function in glucose physiology as a model for the comprehensive study of enzymes' kinetic parameters and reversible inhibitors
(John Wiley & Sons Inc, 2000-12)
Glucokinase is a key enzyme in carbohydrate metabolism in mammals. Particularly relevant is the involvement of the liver enzyme for the maintenance of blood glucose concentrations. In playing this key role, the occurrence ...
Nutrient Sensing by Hypothalamic Tanycytes
(Facultad de Medicina y Ciencia, 2019)
Nutritional signals have long been implicated in the control of cellular processes that take place in the hypothalamus. This includes food intake regulation and energy balance, inflammation, and most recently, neurogenesis. ...