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Cathepsin X cleaves the beta 2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding
(WILEY-V C H VERLAG GMBH, 2009)
The motility of T cells depends on the dynamic spatial regulation of integrin-mediated adhesion and de-adhesion. Cathepsin X, a cysteine protease, has been shown to regulate T-cell migration by interaction with lymphocyte ...
Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort
(BMJ Publishing Group, 2020)
Objective: The Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) clinician-reported outcome (ClinRO) and the LFA-REAL patient-reported outcome (PRO) were developed in order to capture manifestations ...
The role of the B7-1/2, LFA-3 and ICAM-1 costimulatory molecules in the modulation of T cell responses
(2002)
The physiological activation of T cells to proliferation and cytokine production requires at least two signals. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to T cell, while the second ...
Papel da integrina LFA-1 e do receptor de quimiocina CX3CR1 na diferenciação e ativação de linfócitos T CD8+ durante a infecção experimental pelo Trypanosoma cruzi
(Universidade Federal de São Paulo, 2022-05-31)
Os linfócitos T CD8+ são cruciais no controle de infecções por patógenos intracelulares como Trypanosoma cruzi. As moléculas de quimiocinas e integrinas são essenciais para a migração dos linfócitos T. No entanto, são ...
Adhesion molecules in lesions of American cutaneous leishmaniasis
(Experimental Dermatology, 2016)
A importância da molécula de adesão lfa-1 na imunidade adquirida pela vacinação genética do tipo imunização e reforço heterólogo contra a infecção pelo trypanosoma cruzi
(Universidade Federal de São Paulo (UNIFESP), 2014-07-31)
Heterologous prime-boost vaccination strategy using recombinant plasmid DNA followed by replication-defective human recombinant adenovirus type 5 (AdHu5) is a powerful strategy to elicit specific CD4+ and CD8+ T cells which ...