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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
(Pergamon-Elsevier Science Ltd, 2004-04)
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases ...
Effects of protein kinase and phosphatidylinositol-3 kinase inhibitors on growth and ultrastructure of Trypanosoma cruzi
(Oxford University Press, 2020)
Protein Kinase Inhibitors in Rheumatology
(BioMed CentralGrupo de Reumatología Universidad de Antioquia -GRUA-Londres, Inglaterra, 2023)
Structure-based prediction of Mycobacterium tuberculosis shikimate kinase inhibitors by high-throughput virtual screening
(Bioorganic & Medicinal Chemistry letters, 2008-06-01)
Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
(BioMed Central, 2011-10)
Background: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important ...
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...