Now showing items 1-10 of 265
Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity
(Sociedad de Biología de Chile, 2005)
Requirements for PKC-augmented JNK activation by MKK4/7
The c-Jun N-terminal kinases (JNKs) are activated in response to stress, DNA damage, and cytokines by MKK4 and MKK7. We recently demonstrated that PKC can augment the degree of JNK activation by phosphorylating JNK, which ...
JNK mediates TGF-beta 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
In this study we analyzed the role of the c-Jun N-terminal kinases (JNK) pathway in the TGF-beta 1 stimulation of urokinase-type plasminogen activator (uPA), initial stages of epithelial-mesenchymal transdifferentiation ...
Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome
(Scientific Research, 2011-10)
Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) ...
Proinsulin C-peptide induces c-Jun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cells
(HOKKAIDO UNIV, 2009)
To characterize the roles of C-peptide in vascular homeostatic processes, we examined the genes regulated by C-peptide in LEII mouse lung microvascular endothelial cells. Treatment of the cells with C-peptide increased the ...
PTH regulation of c-Jun Terminal Kinase and p38 MAPK Cascades in cells from young and aged rats
In the present study, we examined the role of Parathyroid hormone (PTH) on the c-Jun N-terminal kinase (JNK) 1/2 and p38 mitogen- activated protein kinase (MAPK) members of the MAPK family as it relates to ageing by measuring ...
Low salt intake modulates insulin signaling, JNK activity and IRS-1(ser307) phosphorylation in rat tissues
(Soc EndocrinologyBristolInglaterra, 2005)
17β-estradiol abrogates apoptosis inhibiting PKCδ, JNK and p66Shc activation in C2C12 cells
17β-Estradiol (E2) protects several non-reproductive tissues from apoptosis, including skeletal muscle. Previously, we showed that E2 at physiological concentrations prevented apoptosis induced by H2O2 in skeletal myoblasts. ...
c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-02-15)
In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB-EGF depend on the activity of c-jun amino-terminal kinase (JNK) in human prostatic DU-145 cells. These cells ...