Buscar
Mostrando ítems 1-10 de 120
Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death
(Academic Press Inc., 2015)
In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action ...
TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death
(Taylor & Francis, 2017)
Cerebral ischemia-reperfusion injury triggers a deleterious process ending in neuronal death. This process has two components, a glutamate-dependent and a glutamate-independent mechanism. In the glutamate-independent ...
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart
(ELSEVIER, 2012-04)
Pharmacological preconditioning limits myocardial infarct size after ischemia/reperfusion. Dexmedetomidine is an alpha(2)-adrenergic receptor agonist used in anesthesia that may have cardioprotective properties against ...
Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion
(2010)
Calpains contribute to reperfusion-induced myocardial cell death. However, it remains controversial whether its activation occurs during ischemia or reperfusion. We investigated the regulation and time-course of calpain ...
TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
(2013)
Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a
critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...
Cellular mechanisms against ischemia reperfusion injury induced by the use of anesthetic pharmacological agents
(Elsevier, 2014)
Ischemia–reperfusion (IR) cycle in the myocardium is associated with activation of an injurious cascade,
thus leading to new myocardial challenges, which account for up to 50% of infarct size. Some evidence
implicates ...
Potentiation of ischemia-reperfusion liver injury by hyperthyroidism in the rat
(1997)
Parameters related to hepatic oxidative stress, cell injury, and liver histology were determined in control rats and in animals treated with 3,3',5- triiodothyronine (T3), after in vitro perfusion under normoxic or ischemia- ...
Factors associated with silent myocardial ischemia, autonomic or peripheral neuropathies, and survival in diabetes mellitus type 2 patients without cardiovascular symptoms
(Springer, 2020)
Introduction Complications from diabetes mellitus (DM) include cardiovascular system, peripheral neuropathy (PN), and autonomic dysfunction (AD). Goal: Assess the association of silent myocardial ischemia, AD, and PN in ...
Effect of magnesium treatment and glucose levels on delayed cerebral ischemia in patients with subarachnoid hemorrhage: A substudy of the Magnesium in Aneurysmal Subarachnoid Haemorrhage trial (MASH-II)
(Blackwell Publishing Ltd, 2015)
© 2015 World Stroke Organization. Background: Magnesium treatment did not improve outcome in patients with aneurysmal subarachnoid haemorrhage in the Magnesium in Aneurysmal Subarachnoid Haemorrhage II trial. We hypothesized ...
Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling
(Springer, 2016)
Although it is widely accepted that apoptosis
may contribute to cell death in myocardial infarction,
experimental evidence suggests that adult cardiomyocytes
repress the expression of the caspase-dependent apoptotic
pathway. ...